从 （Kovalevsk.）Kovalevsk. 中分离细胞毒性倍半萜内酯。
Isolation of cytotoxic sesquiterpene lactones from the (Kovalevsk.) Kovalevsk.
机构信息
Department of Chemistry of Coumarins and Terpenoids, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Department of Physical Methods of Research, Acad. S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
出版信息
Nat Prod Res. 2021 Jun;35(12):1939-1948. doi: 10.1080/14786419.2019.1647423. Epub 2019 Jul 30.
The structures and anticancer effects of two sesquiterpene lactones, 1 ,10,3,4-diepoxyguai-5,6,7-11(13)-en-6,12-olide () and hanphyllin () isolated from the aerial part of (Kovalevsk.) Kovalevsk were investigated. The compound was isolated for the first time as a natural compound and its structure was investigated by HR-ESI-MS, IR and NMR techniques. The X-ray diffraction analysis was performed to accurately determine the spatial structures of and . Furthermore, we evaluated the cytotoxic activity of and and the chloroform fraction which contains both of them. Cytotoxic activity revealed that the effect of the chloroform fraction is stronger in growth inhibition of HeLa (89.7%) and HEp-2 (63.0%) cancer cells than the effect of individual compounds (55.9 and 36.3%), (78.6 and 50.3%) and the reference cisplatin (58.0 and 46.8%) respectively. Moreover, the chloroform fraction is less toxic to the hepatocytes.
研究了从 （Kovalevsk.）Kovalevsk 的地上部分分离得到的两种倍半萜内酯 1,10,3,4-环氧愈创木-5,6,7-11(13)-烯-6,12-内酯 () 和汉菲林 () 的结构和抗癌作用。化合物 是首次作为天然化合物被分离出来的，其结构通过高分辨电喷雾质谱（HR-ESI-MS）、红外（IR）和核磁共振（NMR）技术进行了研究。通过 X 射线衍射分析精确确定了 和 的空间结构。此外，我们评估了 和 的细胞毒性活性以及含有两者的氯仿部分。细胞毒性活性表明，氯仿部分对 HeLa（89.7%）和 HEp-2（63.0%）癌细胞的生长抑制作用强于单个化合物 （55.9 和 36.3%）、 （78.6 和 50.3%）和参考顺铂（58.0 和 46.8%）的作用。此外，氯仿部分对肝细胞的毒性较小。
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