Videtta Alessandro Davide, Malagnino Valeria, De Falco Giulia
183th Paratroop Regiment "Nembo" Italian Army, Pistoia, Italy.
Onco-Haematology Department SS. Annunziata Hospital, Taranto, Italy.
Blood Lymphat Cancer. 2018 May 11;8:33-45. doi: 10.2147/BLCTT.S129618. eCollection 2018.
Since its discovery in 1958, Burkitt lymphoma (BL) has been extensively studied and has become a model for tumorigenesis, but its pathogenesis has not been completely explained and understood yet. The aim of this review was to summarize the current knowledge about BL and, in particular, to discuss the role of miRNAs in its pathogenesis and their possible use as diagnostic and prognostic indicators. The impact of viral-encoded miRNAs is also discussed, with the Epstein-Barr infection being almost invariably detected in the endemic variant of this tumor.
自1958年被发现以来，伯基特淋巴瘤（BL）已得到广泛研究，并成为肿瘤发生的一个模型，但其发病机制尚未得到完全解释和理解。本综述的目的是总结目前关于BL的知识，特别是讨论微小RNA（miRNA）在其发病机制中的作用及其作为诊断和预后指标的潜在用途。还讨论了病毒编码的miRNA的影响，在这种肿瘤的地方性变体中几乎总是检测到爱泼斯坦-巴尔病毒感染。
