Dental Hospital, Jilin University, Changchun 130021, China.
The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China.
Int J Biol Sci. 2019 Jun 4;15(8):1600-1609. doi: 10.7150/ijbs.34716. eCollection 2019.
Natural products, an infinite treasure of bioactive scaffolds, have provided an excellent reservoir for the discovery of drugs since millennium. These naturally occurring, biologically active and therapeutically effective chemical entities have emerged as novel paradigm for the prevention of various diseases. This review aims to give an update on the sources as well as pharmacological profile of curcumol, a pharmacologically active sesquiterpenoid, which is an imperative bioactive constituent of several plants mainly from genus . Curcumol has potential to fight against cancer, oxidative stress, neurodegeneration, microbial infections, and inflammation. Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers. The reported data reveals multitarget activity of curcumol in cancer treatment suggesting its importance as anticancer drug in future. It is speculated that curcumol may provide an excellent opportunity for the cure of cancer but further investigations on mechanism of its action and preclinical trials are still mandatory to further validate the potential of this natural cancer killer in anticancer therapies.
天然产物是生物活性支架的无尽宝藏，千百年来为药物发现提供了极好的来源。这些天然存在的、具有生物活性和治疗效果的化学物质已经成为预防各种疾病的新范例。本综述旨在介绍姜黄素的来源和药理学概况，姜黄素是一种具有药理活性的倍半萜烯，是几种植物的重要生物活性成分，主要来自 属。姜黄素具有对抗癌症、氧化应激、神经退行性疾病、微生物感染和炎症的潜力。姜黄素已被证明通过靶向 MAPK/ERK、PI3K/Akt 和 NF-κB 等关键信号通路，在许多癌细胞中作为有效的凋亡诱导剂，这些信号通路在多种癌症中通常失调。报道的数据显示，姜黄素在癌症治疗中具有多靶点活性，表明它作为抗癌药物在未来的重要性。有人推测，姜黄素可能为癌症治疗提供了一个极好的机会，但仍需要进一步的机制研究和临床前试验来进一步验证这种天然抗癌杀手在癌症治疗中的潜力。
