Ramos Innocentini Lara Maria Alencar, Teixeira Alisson Henrique, Casemiro Luciana Assirati, Andrade Matheus Carrijo, Ferrari Tatiane Cristina, Ricz Hilton Marcos Alves, Macedo Leandro Dorigan de
Dentistry and Stomatology Division, Ophthalmology, Otolaryngology and Head and Neck Surgery Department, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Department of Oral Medicine, Faculdade de Odontologia da Universidade de Franca, Franca, SP, Brazil.
Int Arch Otorhinolaryngol. 2019 Jul;23(3):e299-e304. doi: 10.1055/s-0039-1687909. Epub 2019 May 28.
Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS ( = 0.02) and OS ( = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients ( = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 ( = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients ( = 0.04). Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.
关于巴西人群中与喉癌相关的预后因素的流行病学研究在文献中的报道较少。为了评估某些危险因素对喉鳞状细胞癌（SCC）患者生存率的影响。本回顾性研究针对在一家三级护理医院头颈科门诊就诊的成年患者进行。基于年龄、性别、初始阶段、病程、习惯、教育水平以及复发和死亡情况，对在该医院登记的喉SCC患者中危险因素对生存率的影响进行评估。使用Kaplan-Meier法、对数秩检验和Cox回归分析总生存（OS）、无病生存（DFS）以及临床人口统计学数据。本研究共纳入107例患者，平均年龄59.8岁（范围19 - 81岁）。III期和IV期与DFS降低（P = 0.02）和OS降低（P = 0.02）相关。吸烟患者的病程比不吸烟患者更长（P = 0.003）。与不饮酒的吸烟者相比，吸烟者饮酒会使死亡风险增加2.8倍（P = 0.002）。与女性患者相比，男性患者的DFS平均水平较低（P = 0.04）。我们的研究证实，男性性别、吸烟习惯与饮酒相结合以及晚期阶段与不良预后密切相关。
