Department of Otorhinolaryngology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 45000, China.
Department of Nursing, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 45000, China.
J Healthc Eng. 2021 Nov 26;2021:5614861. doi: 10.1155/2021/5614861. eCollection 2021.
Laryngeal carcinoma (LC) is one of the common human cancer types. MicroRNAs (miRNAs) were reported to be the essential regulators in cancer diagnosis, treatment, and prognosis. It was reported that miR-206 expression was reduced in various neoplastic diseases. However, the role and functional mechanism of miR-206 in LC progression remain unclear. In this research, miR-206 was found to be associated with tumor-node-metastasis (TNM) staging. In addition, the area under the curve (AUC) of miR-206 was 0.902 for diagnosis of LC and 0.854 for differential diagnosis of stage I-II and stage III-IV patients. Low expression of miR-206 was associated with poor prognosis of LC patients. miR-206 expression was an independent factor affecting the prognosis of LC patients, as revealed by the Cox regression analysis. experiments demonstrated that miR-206 overexpression reduced cell multiplication, invasion, and migration and increased cell apoptosis in LC cells. Moreover, SOX9 was a target of miR-206, and miR-206 negatively regulated SOX9 expression. Collectively, miR-206 might be a promising biomarker with diagnostic and prognostic value for LC, and the miR-206/SOX9 axis might be a candidate target for LC therapy.
喉癌（LC）是人类常见的癌症类型之一。microRNAs（miRNAs）被报道在癌症的诊断、治疗和预后中是重要的调控因子。据报道，miR-206 在各种肿瘤性疾病中的表达降低。然而，miR-206 在 LC 进展中的作用和功能机制仍不清楚。在这项研究中，发现 miR-206 与肿瘤-淋巴结-转移（TNM）分期有关。此外，miR-206 诊断 LC 的曲线下面积（AUC）为 0.902，诊断 I-II 期和 III-IV 期患者的 AUC 为 0.854。miR-206 低表达与 LC 患者的不良预后相关。Cox 回归分析显示，miR-206 表达是影响 LC 患者预后的独立因素。实验表明，miR-206 过表达可降低 LC 细胞的增殖、侵袭和迁移，增加细胞凋亡。此外，SOX9 是 miR-206 的靶基因，miR-206 负调控 SOX9 的表达。总之，miR-206 可能是一种有前途的 LC 诊断和预后标志物，miR-206/SOX9 轴可能是 LC 治疗的候选靶点。
