唐氏综合征、黏液性水肿和心源性休克患儿初始低剂量口服左甲状腺素治疗
Initial low-dose oral levothyroxine in a child with Down syndrome, myxedema, and cardiogenic shock.
作者信息
Janson Annika, Hällström Cathrin, Iversen Magnus, Finder Mikael, Elimam Amira, Nergårdh Ricard
机构信息
Department of Pediatrics Karolinska University Hospital Huddinge Huddinge Sweden.
Department of Children's and Women's Health Karolinska Institutet Solna Sweden.
出版信息
Clin Case Rep. 2019 May 20;7(7):1291-1296. doi: 10.1002/ccr3.2169. eCollection 2019 Jul.
Myxedema is extremely rare in children, and guidelines are lacking. We treated a 12-year-old girl with myxedema and cardiogenic shock with initial low dose (0.3-2.5 μg/kg body weight/day) of oral levothyroxine and intensive care. Oral administration may safely revert children's myxedema in a dosage resembling that for hypothyroidism.
黏液性水肿在儿童中极为罕见，且缺乏相关指南。我们对一名患有黏液性水肿和心源性休克的12岁女孩进行了治疗，初始给予低剂量（0.3 - 2.5μg/千克体重/天）的口服左甲状腺素并进行重症监护。口服给药可能以类似于治疗甲状腺功能减退症的剂量安全地逆转儿童黏液性水肿。
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