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Recommendations for the management of hemophagocytic lymphohistiocytosis in adults.成人噬血细胞性淋巴组织细胞增生症的治疗建议。
Blood. 2019 Jun 6;133(23):2465-2477. doi: 10.1182/blood.2018894618. Epub 2019 Apr 16.
2
Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH.可溶性白细胞介素-2受体是成人噬血细胞性淋巴组织细胞增生症的一项敏感诊断检测。
Blood Adv. 2017 Dec 6;1(26):2529-2534. doi: 10.1182/bloodadvances.2017012310. eCollection 2017 Dec 12.
3
How I treat hemophagocytic lymphohistiocytosis in the adult patient.成人噬血细胞性淋巴组织细胞增生症的治疗方法。
Blood. 2015 May 7;125(19):2908-14. doi: 10.1182/blood-2015-01-551622. Epub 2015 Mar 10.
4
Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome.HScore 的制定与验证：一种用于诊断反应性噬血细胞综合征的评分系统。
Arthritis Rheumatol. 2014 Sep;66(9):2613-20. doi: 10.1002/art.38690.
5
Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.噬血细胞性淋巴组织细胞增生症的化免疫治疗：HLH-94 治疗方案的长期结果。
Blood. 2011 Oct 27;118(17):4577-84. doi: 10.1182/blood-2011-06-356261. Epub 2011 Sep 6.
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Early diagnostic and prognostic significance of a specific Th1/Th2 cytokine pattern in children with haemophagocytic syndrome.特定Th1/Th2细胞因子模式在噬血细胞综合征患儿中的早期诊断及预后意义
Br J Haematol. 2008 Oct;143(1):84-91. doi: 10.1111/j.1365-2141.2008.07298.x. Epub 2008 Jul 31.
7
Treatment of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) in young adults: a report from the HLH study center.青年成人中爱泼斯坦-巴尔病毒相关噬血细胞性淋巴组织细胞增生症（EBV-HLH）的治疗：HLH研究中心报告
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Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation.采用HLH - 94免疫化疗及骨髓移植治疗噬血细胞性淋巴组织细胞增生症。
Blood. 2002 Oct 1;100(7):2367-73. doi: 10.1182/blood-2002-01-0172.
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Pathogenesis of haemophagocytic lymphohistiocytosis.噬血细胞性淋巴组织细胞增生症的发病机制。
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一例成人弥漫性大B细胞淋巴瘤合并噬血细胞性淋巴组织细胞增生症的罕见病例。

A Rare Case of Hemophagocytic Lymphohistiocytosis in an Adult with Diffuse Large B-Cell Lymphoma.

作者信息

Mbachi Chimezie, Igwilo Rita, Flores Estefania, Chukwujindu Ezekiel, Mba Benjamin

机构信息

Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL 60612, USA.

Internal Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.

出版信息

Case Rep Hematol. 2019 Jul 7;2019:7530698. doi: 10.1155/2019/7530698. eCollection 2019.

DOI:10.1155/2019/7530698
PMID:31360558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6642749/
Abstract

A 71-year-old Indian female presented with a 3-month history of weight loss and fatigue. Further review confirmed a histological diagnosis of diffuse large B-cell lymphoma. Although bone marrow analysis did not reveal hemophagocytosis, she had some clinical and laboratory pointers to hemophagocytic lymphohistiocytosis (HLH). Her clinical state deteriorated rapidly with development of acute respiratory distress syndrome, diffuse alveolar hemorrhage, and subsequently death.

摘要

一名71岁的印度女性，有3个月体重减轻和疲劳的病史。进一步检查确诊为弥漫性大B细胞淋巴瘤。尽管骨髓分析未发现噬血细胞现象，但她有一些提示噬血细胞性淋巴组织细胞增生症（HLH）的临床和实验室指标。她的临床状况迅速恶化，出现急性呼吸窘迫综合征、弥漫性肺泡出血，随后死亡。