Shi Han-Yu, Li Xue-Ren, Wei Lu-Qing, Peng Shou-Chun
Department of Respiratory and Critical Care Medicine, Special Medical Center of Chinese People's Armed Police Force, Tianjin, 300309, China.
Logistics University of Chinese People's Armed Police Force, Tianjin, 300309, China.
Respir Med Case Rep. 2019 Jul 3;28:100896. doi: 10.1016/j.rmcr.2019.100896. eCollection 2019.
Patients of clinically amyopathic dermatomyositis associated with rapidly progressive interstitial pneumonia (CADM-RFIP) with positive anti-MDA5 antibody usually presents rapid deterioration and traditional therapy such as cyclophosphamide combined with high-dose prednisone pulse therapy shows no clear benefit at whiles. However, blood purification combined with traditional therapy works according to the literature. We herein report two CADM-RFIP patients administered with DNA immunoadsorption combined with traditional therapy and then reviewed the literature of blood purification in CADM-RFIP patients at home and abroad to date. We emphasize blood purification such as DNA immunoadsorption could apply in the early stage of CADM-RFIP, which can decrease inflammation and allow us more time to control the condition better.
抗MDA5抗体阳性的临床无肌病性皮肌炎合并快速进展性间质性肺炎（CADM-RFIP）患者通常病情迅速恶化，而环磷酰胺联合大剂量泼尼松脉冲治疗等传统疗法有时并无明显益处。然而，根据文献报道，血液净化联合传统疗法有效。我们在此报告了2例接受DNA免疫吸附联合传统疗法的CADM-RFIP患者，并回顾了迄今为止国内外关于CADM-RFIP患者血液净化的文献。我们强调，DNA免疫吸附等血液净化疗法可应用于CADM-RFIP的早期，这可以减轻炎症，让我们有更多时间更好地控制病情。
