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Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer.

作者信息

Kaochar Salma, Mitsiades Nicholas

机构信息

Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

Transl Cancer Res. 2019 Mar;8(Suppl 2):S198-S203. doi: 10.21037/tcr.2019.02.08.

DOI:10.21037/tcr.2019.02.08
PMID:31360645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6662936/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c05/8798904/6f0fe27cec65/tcr-08-S2-S198-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c05/8798904/6f0fe27cec65/tcr-08-S2-S198-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c05/8798904/6f0fe27cec65/tcr-08-S2-S198-f1.jpg

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Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer.ONECUT2在驱动神经内分泌前列腺癌中的多模态作用。
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Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms.前列腺癌对第二代抗雄激素的耐药性：途径与机制
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本文引用的文献

1
ONECUT2 is a driver of neuroendocrine prostate cancer.ONECUT2 是神经内分泌前列腺癌的驱动基因。
Nat Commun. 2019 Jan 17;10(1):278. doi: 10.1038/s41467-018-08133-6.
2
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.ONECUT2 是一种可靶向的致命前列腺癌主调控因子，可抑制雄激素轴。
Nat Med. 2018 Dec;24(12):1887-1898. doi: 10.1038/s41591-018-0241-1. Epub 2018 Nov 26.
3
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
ONECUT2作为雄激素受体非依赖性前列腺癌的新治疗靶点。
Transl Cancer Res. 2019 Nov;8(7):2677-2679. doi: 10.21037/tcr.2019.10.15.
治疗后出现的小细胞神经内分泌前列腺癌的临床和基因组特征：一项多机构前瞻性研究。
J Clin Oncol. 2018 Aug 20;36(24):2492-2503. doi: 10.1200/JCO.2017.77.6880. Epub 2018 Jul 9.
4
Blockade of ONECUT2 expression in ovarian cancer inhibited tumor cell proliferation, migration, invasion and angiogenesis.阻断卵巢癌细胞中 ONECUT2 的表达可抑制肿瘤细胞的增殖、迁移、侵袭和血管生成。
Cancer Sci. 2018 Jul;109(7):2221-2234. doi: 10.1111/cas.13633. Epub 2018 Jun 13.
5
Clinical and molecular features of treatment-related neuroendocrine prostate cancer.治疗相关神经内分泌前列腺癌的临床和分子特征
Int J Urol. 2018 Apr;25(4):345-351. doi: 10.1111/iju.13526. Epub 2018 Feb 3.
6
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance.前列腺癌中胃肠道转录回路的异常激活介导去势抵抗。
Cancer Cell. 2017 Dec 11;32(6):792-806.e7. doi: 10.1016/j.ccell.2017.10.008. Epub 2017 Nov 16.
7
Onecut transcription factors in development and disease.发育和疾病中的Onecut转录因子。
Trends Dev Biol. 2016;9:43-57.
8
The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer.主要神经转录因子 BRN2 是雄激素受体抑制的前列腺癌神经内分泌分化的驱动因素。
Cancer Discov. 2017 Jan;7(1):54-71. doi: 10.1158/2159-8290.CD-15-1263. Epub 2016 Oct 26.
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Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.超越雄激素受体（AR）：靶向AR相互作用蛋白治疗前列腺癌
Horm Cancer. 2016 Apr;7(2):84-103. doi: 10.1007/s12672-015-0239-9. Epub 2016 Jan 4.
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Cell Rep. 2015 Aug 11;12(6):922-36. doi: 10.1016/j.celrep.2015.07.012. Epub 2015 Jul 30.