Yu Jia, Li Dongyang, Jiang Hua
Department of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.
Department of Urology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.
Oncol Lett. 2020 Dec;20(6):328. doi: 10.3892/ol.2020.12192. Epub 2020 Oct 6.
One cut domain family member 2 (ONECUT2), also termed OC-2, is a newly discovered member of the ONECUT transcription factor family. As a transcription factor, ONECUT2 can widely regulate protein expression associated with cell proliferation, migration, adhesion, differentiation and cell material metabolism. Recent studies have revealed that ONECUT2 is associated with tumor cell proliferation, angiogenesis and metastasis; it is also associated with epithelial-mesenchymal transition in cancer cells. The present review examines the distribution and expression of ONECUT2 in a variety of tumors, its oncogenic role in tumor progression and the possible mechanisms of regulation. Given the emerging role of ONECUT2 in the development and progression of tumors, ONECUT2 might be a promising target for tumor therapy.
单剪接结构域家族成员2（ONECUT2），也称为OC-2，是单剪接转录因子家族新发现的成员。作为一种转录因子，ONECUT2可广泛调节与细胞增殖、迁移、黏附、分化及细胞物质代谢相关的蛋白质表达。近期研究表明，ONECUT2与肿瘤细胞增殖、血管生成和转移有关；它还与癌细胞的上皮-间质转化有关。本综述探讨了ONECUT2在多种肿瘤中的分布和表达、其在肿瘤进展中的致癌作用以及可能的调控机制。鉴于ONECUT2在肿瘤发生发展中的新作用，它可能是肿瘤治疗的一个有前景的靶点。
