在Fischer 344大鼠中具有高肺转移潜能的可移植骨肉瘤。
Transplantable osteosarcomas with high lung metastatic potential in Fischer 344 rats.
作者信息
Mii Y, Tsutsumi M, Shiraiwa K, Miyauchi Y, Hohnoki K, Maruyama H, Ogushi H, Masuhara K, Konishi Y
机构信息
Department of Orthopedic Surgery, Nara Medical College.
出版信息
Jpn J Cancer Res. 1988 May;79(5):589-92. doi: 10.1111/j.1349-7006.1988.tb00027.x.
Both spontaneous (SOS) and 4-hydroxyaminoquinoline 1-oxide (4-HAQO)-induced osteosarcomas (COS) could be serially transplanted in the subcutaneous back space of syngeneic F344 rats, the success rate becoming 100% within 5 passage generations. Transplanted tumors demonstrated rapid growth and displayed high potential for metastasis to the lung in later generations. Thus, a 100% lung metastasis rate was observed for SOS after the 20th and for COS after the 14th generation. The histological features of the primary SOS and COS were retained during serial transfer. These model systems should be useful for investigation of the biology of this very important tumor type.
自发性骨肉瘤（SOS）和4-羟基氨基喹啉1-氧化物（4-HAQO）诱导的骨肉瘤（COS）都可以在同基因F344大鼠的背部皮下间隙进行连续传代移植，在5代传代内成功率达到100%。移植瘤生长迅速，在后代中显示出高肺转移潜能。因此，在第20代后观察到SOS的肺转移率为100%，在第14代后COS的肺转移率为100%。原发性SOS和COS的组织学特征在连续传代过程中得以保留。这些模型系统对于研究这种非常重要的肿瘤类型的生物学特性应该是有用的。
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