雄激素治疗对老年NZB/NZW F1杂交小鼠生存及抑制细胞活性的影响。
Effect of androgen therapy on survival and suppressor cell activity in aged NZB/NZW F1 hybrid mice.
作者信息
Michalski J P, McCombs C C, Roubinian J R, Talal N
出版信息
Clin Exp Immunol. 1983 Apr;52(1):229-33.
Abstract
Male NZB/NZW F1 hybrid (B/W) mice survive their first year of life and die of lupus nephritis or lymphoid malignancy during the second year. Androgen therapy, even if delayed until 9 months of age, improves survival considerably. We report here that androgen therapy in aged B/W mice is associated with improved cell-mediated immune function as well as increased survival. Androgen treated mice have significantly augmented spleen cell responses to phytohaemagglutinin (PHA) and a decreased incidence of abnormal splenic suppressor activity. These results suggest that androgen may prolong survival in B/W mice in part through an effect on abnormally suppressive regulatory cells that impair T lymphocyte function.
摘要
雄性新西兰黑/新西兰白F1杂交（B/W）小鼠能活过一岁，并在第二年死于狼疮性肾炎或淋巴系统恶性肿瘤。雄激素治疗，即使推迟到9个月龄，也能显著提高生存率。我们在此报告，老年B/W小鼠接受雄激素治疗后，细胞介导的免疫功能得到改善，生存率也有所提高。接受雄激素治疗的小鼠对植物血凝素（PHA）的脾细胞反应显著增强，脾抑制活性异常的发生率降低。这些结果表明，雄激素可能部分通过对损害T淋巴细胞功能的异常抑制性调节细胞产生作用，从而延长B/W小鼠的生存期。
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