Murray F T, Cameron D F, Vogel R B, Thomas R G, Wyss H U, Zauner C W
Departments of Medicine, University of Florida, Gainesville 32610.
J Androl. 1988 May-Jun;9(3):197-206. doi: 10.1002/j.1939-4640.1988.tb01034.x.
Hormonal studies of pituitary-testicular function in insulin-dependent diabetes mellitus were examined at rest and during moderate exercise to assess whether diabetes per se caused abnormalities of nocturnal penile tumescence and androgen function in men with normal sexual function. The present study compared 10 healthy men and eight men with Type I diabetes mellitus in whom normal sexual function was determined by clinical history. Urinary gonadotropin excretion, semen analysis and diurnal variation of serum glucose, prolactin, testosterone and free testosterone were determined in both groups. In addition, the serum levels of testosterone, free testosterone, prolactin, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured at rest, during 45 minutes of exercise on a bicycle ergometer at 50% of the subjects previously determined maximal oxygen uptake (VO2 max) and during a 30-minute recovery period. Nocturnal penile tumescence and parameters of semen analysis were similar in both groups. Urinary FSH excretion and serum FSH were higher (P less than or equal to 0.01) in the diabetic subjects while urinary LH excretion was similar. Diurnal variation of serum prolactin, testosterone and free testosterone were similar in both groups. Exercise produced a significant (P less than or equal to 0.01) increase in maximal free and total testosterone in both groups without changes in serum FSH or LH. Prolactin increased significantly (P less than or equal to 0.01) during exercise in the diabetic group only. We conclude that, for the most part, the pituitary-testicular axis and nocturnal penile tumescence under basal conditions and the pituitary-testicular axis during moderate exercise are similar in healthy males and insulin-dependent diabetic males with normal sexual function.
对胰岛素依赖型糖尿病患者的垂体 - 睾丸功能进行了激素研究，分别在静息状态和适度运动期间进行检测，以评估糖尿病本身是否会导致性功能正常的男性出现夜间阴茎勃起异常和雄激素功能异常。本研究比较了10名健康男性和8名1型糖尿病男性，后者的性功能通过临床病史确定为正常。测定了两组的尿促性腺激素排泄量、精液分析以及血清葡萄糖、催乳素、睾酮和游离睾酮的昼夜变化。此外，在静息状态、在自行车测力计上以受试者先前测定的最大摄氧量（VO2 max）的50%进行45分钟运动期间以及30分钟恢复期内，测量了血清睾酮、游离睾酮、催乳素、促卵泡激素（FSH）和促黄体生成素（LH）的水平。两组的夜间阴茎勃起和精液分析参数相似。糖尿病患者的尿FSH排泄量和血清FSH较高（P≤0.01），而尿LH排泄量相似。两组血清催乳素、睾酮和游离睾酮的昼夜变化相似。运动使两组的最大游离睾酮和总睾酮显著增加（P≤0.01），而血清FSH或LH无变化。仅糖尿病组在运动期间催乳素显著增加（P≤0.01）。我们得出结论，在大多数情况下，性功能正常的健康男性和胰岛素依赖型糖尿病男性在基础条件下的垂体 - 睾丸轴和夜间阴茎勃起以及适度运动期间的垂体 - 睾丸轴相似。
