Department of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.
Curr Opin Crit Care. 2019 Oct;25(5):523-529. doi: 10.1097/MCC.0000000000000648.
This review summarizes the results from long-term intensive care outcome research over the past 50 years. Key findings from early studies are reflected in citations of contemporary research.
The postintensive care syndrome (PICS) is a multifaceted entity of residual disability and complications burdening survivors of critical illness. Some interventions applied early in the history of outcomes research have now been confirmed as effective in counteracting specific PICS components.
Interest in patient-centred outcomes has been present since the beginning of modern intensive care. Findings from early long-term studies remain valid even in the face of contemporary large registries that facilitate follow-up of larger cohorts. A further understanding of the mechanisms leading to experienced physical and psychological impairment of PICS will be essential to the design of future intervention trials.
本文总结了过去 50 年中重症监护结局研究的长期结果。早期研究的主要发现反映在当代研究的引用中。
重症监护后综合征（PICS）是一种多方面的残障和并发症实体，困扰着危重病幸存者。在结局研究的早期历史中应用的一些干预措施现在已被证实可有效对抗特定的 PICS 成分。
自现代重症监护开始以来，人们就一直关注以患者为中心的结局。即使面对现代大型登记处，使更大队列的随访成为可能，早期的长期研究结果仍然有效。进一步了解导致 PICS 经历身体和心理损伤的机制对于未来干预试验的设计至关重要。
