Departament of Obstetrics and Gynecology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Menopause. 2019 Oct;26(10):1133-1140. doi: 10.1097/GME.0000000000001381.
The aim of this study was to evaluate medication use during the climacteric period and assess its association with sociodemographic factors, morbidities, and climacteric symptoms.
Secondary analysis of data from a previous exploratory cross-sectional population-based study, conducted with 749 women (45-60 y), with the help of home interviews. Associations between medication use and climacteric symptoms were analyzed, and their correlations with other variables were made. Univariate analysis was made using the χ test, followed by Bonferroni correction (multiple comparison method). Values were adjusted for age using the polytomic logistic multivariate regression analysis. Using Poisson regression analysis, simple and multiple, we identified the main factors for medication use, with forward stepwise variable selection criteria (95% CI).
The mean age was 52.5 years and menopause occurred at 46.5 years (mean). The overall prevalence of medication use was 68.8%. The use of exclusive medications for relieving climacteric symptoms was associated with the absence of diseases (prevalence ratio [PR] = 8.2; 95% CI = 3.5-18.9; P<0.001) and menopause onset between 40 and 44 years (PR = 4.9; 95% CI = 2.0-11.9; P<0.001). Polypharmacy was associated with the highest number of diseases (PR = 10.6; 95% CI = 4.6-24.2; P<0.001) and somatic Menopause Rating Scale (MRS) score >3 (PR = 1.4; 95% CI = 1.01-1.96; P = 0.044).
The prevalence of medication use among middle-aged women was high and was associated with the age of menopause onset, chronic diseases, and obesity/overweight status.
本研究旨在评估更年期期间的药物使用情况，并评估其与社会人口学因素、疾病和更年期症状的关系。
对之前一项基于人群的探索性横断面研究的数据进行二次分析，该研究使用家庭访谈的方式对 749 名（45-60 岁）女性进行了研究。分析了药物使用与更年期症状之间的关系，并对其与其他变量的相关性进行了分析。采用 χ²检验进行单变量分析，然后进行 Bonferroni 校正（多重比较方法）。使用多元逻辑回归分析（多分类），根据年龄进行校正。使用泊松回归分析，简单和多重，我们确定了药物使用的主要因素，并采用向前逐步变量选择标准（95%CI）。
平均年龄为 52.5 岁，绝经年龄为 46.5 岁（平均值）。药物总使用率为 68.8%。仅用于缓解更年期症状的药物的使用与无疾病（患病率比 [PR] = 8.2；95%CI = 3.5-18.9；P<0.001）和 40-44 岁绝经（PR = 4.9；95%CI = 2.0-11.9；P<0.001）相关。多种药物联合使用与疾病数量最多（PR = 10.6；95%CI = 4.6-24.2；P<0.001）和躯体绝经评定量表（MRS）评分>3（PR = 1.4；95%CI = 1.01-1.96；P = 0.044）相关。
中年女性药物使用率较高，与绝经年龄、慢性疾病和肥胖/超重有关。
