Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang 421001, China.
Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang 421001, China.
Gene. 2019 Oct 5;715:144008. doi: 10.1016/j.gene.2019.144008. Epub 2019 Jul 27.
Deinococcus radiodurans is a model microorganism used for studies on DNA repair and antioxidation due to its extraordinary tolerance to ionizing radiation and other DNA-damaging agents. Various transcriptome analyses have revealed that hundreds of genes are induced and that many other genes are repressed during recovery of D. radiodurans following irradiation, suggesting that gene regulation is of great importance for the extreme resistance of this microorganism to ionizing radiation. In this article, we focus on some reported strategies that are employed by D. radiodurans to regulate the genes implicated in its extreme tolerance to ionizing radiation for a comprehensive understanding of the reasons this bacterium can survive such extraordinary stress. We expect this review to shed light on potential radioprotective agents and applications for use in a range of fields.
耐辐射球菌是一种模式微生物，由于其对电离辐射和其他 DNA 损伤剂的非凡耐受性，常被用于研究 DNA 修复和抗氧化作用。各种转录组分析表明，在耐辐射球菌受到照射后恢复过程中，数百个基因被诱导，许多其他基因被抑制，这表明基因调控对于这种微生物对电离辐射的极端抗性非常重要。在本文中，我们重点介绍了耐辐射球菌用于调节与极端耐受电离辐射相关基因的一些报道策略，以全面了解该细菌能够在如此极端压力下存活的原因。我们希望这篇综述能为潜在的辐射防护剂提供启示，并在多个领域得到应用。
