Luigi Sacco Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy -
III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy -
Panminerva Med. 2019 Dec;61(4):464-472. doi: 10.23736/S0031-0808.19.03723-6. Epub 2019 Jul 30.
Chagas disease (CD) is an emerging infection in Italy as the consequence of the huge immigration from Latin American countries observed during the last ten-fifteen years. However, the interest of Italian researchers on CD dates back to the '80-90s of the last century with studies conducted in collaboration with Brazilian and Argentinian colleagues by Italian cardiologists and pathologists. Moreover, the first demonstration of the existence in the pre-Columbian America of Chagas disease in a Peruvian mummy was made by a group of Italian paleopathologists. Seroprevalence studies performed between 2010-2014 in Negrar (Verona), Bergamo, Milan, Florence and Rome shows Trypanosoma cruzi infection ranging from 3.9% to 17.1% with people coming from Bolivia as the most affected. As observed in Latin America about 30% of screened subjects in Italy are affected by cardiac or digestive forms of CD. More than 20% of subjects treated with benznidazole discontinued it permanently due to adverse events.
恰加斯病（CD）是意大利的一种新出现的传染病，是过去十五年中来自拉丁美洲国家的大量移民造成的。然而，意大利研究人员对 CD 的兴趣可以追溯到上世纪 80-90 年代，当时意大利心脏病学家和病理学家与巴西和阿根廷的同事合作开展了研究。此外，意大利古病理学家首次证明了在哥伦布发现美洲之前，在秘鲁的木乃伊中就存在恰加斯病。2010-2014 年间在维罗纳的内格拉、贝加莫、米兰、佛罗伦萨和罗马进行的血清流行率研究显示，克氏锥虫感染率从 3.9%到 17.1%不等，玻利维亚人受感染的情况最为严重。与拉丁美洲的情况一样，在意大利，大约 30%接受筛查的人患有心脏或消化系统形式的 CD。超过 20%接受苯并咪唑治疗的患者因不良反应而永久停药。
