Max Planck Institute of Psychiatry, Munich, Germany; Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece.
Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Trends Neurosci. 2019 Sep;42(9):573-588. doi: 10.1016/j.tins.2019.07.002. Epub 2019 Jul 29.
Accumulating data highlight the contribution of brain mitochondria and bioenergetics to psychiatric disorders and stress-related pathologies. Although anxiety has not received much attention in this booming literature, a bidirectional interplay between anxiety and brain mitochondria and metabolism has recently started to emerge. Substantial observations indicate alterations in mitochondria and metabolism in highly anxious individuals and, conversely, anxiety symptoms in humans suffering from mitochondrial disorders. Genetic and pharmacological efforts have made substantial progress at advancing the causal involvement of specific mitochondrial and metabolic factors in anxiety. In this review, we discuss this converging evidence and highlight the relevance of developing a research focused on targeting mitochondria as an approach to alleviate anxiety.
越来越多的数据强调了大脑线粒体和生物能量学对精神疾病和应激相关病理的贡献。尽管在这一蓬勃发展的研究领域中，焦虑并未受到太多关注，但焦虑与大脑线粒体和代谢之间的双向相互作用最近开始显现。大量研究表明，高度焦虑个体的线粒体和代谢存在改变，而患有线粒体疾病的人类则出现焦虑症状。遗传和药理学方面的努力在推进特定线粒体和代谢因素在焦虑中的因果关系方面取得了重大进展。在这篇综述中，我们讨论了这些趋同的证据，并强调了将靶向线粒体作为一种减轻焦虑的方法作为研究重点的重要性。
