炎症性肠病与幽门螺杆菌血清阳性之间的负相关关系。
The negative association between inflammatory bowel disease and Helicobacter pylori seropositivity.
作者信息
Sayar Rasoul, Shokri Shirvani Javad, Hajian-Tilaki Karimollah, Vosough Zeinab, Ranaei Mohammad
机构信息
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
出版信息
Caspian J Intern Med. 2019 Spring;10(2):217-222. doi: 10.22088/cjim.10.2.217.
BACKGROUND
The role of Helicobacter pylori (H. pylori) in inflammatory bowel disease is a controversial argument. The initial theory of this study was that Helicobacter is a risk factor for inflammatory bowel disease. In this study, we investigated the coincidence of H. pylori exposure and IBDs.
METHODS
This case-control study has been done in Babol, teaching Hospitals; 60 newly diagnosed IBD cases without any Helicobacter eradicating treatment and 120 control patients without inflammatory bowel disease evidence in biopsy, investigated for H. pylori exposure by IgA and IgG ELISA tests. Clinical information, demographics and ELISA test results have been analyzed using SPSS.Version.18 (level of significance was less than 0.05).
RESULTS
Mean age of case group was 42.27±13.64 years; in control group it was 45.52±13.83 years. There was a significant difference between the case and control groups in IgG study of the following subgroups: age under 30, females, males, urban, higher education level and BMI between 18.5 and 24.9 (p-value was respectively; 0.004, 0.014, 0.047, 0.002, 0.013, 0.003). On the basis of logistic regression; IBD was less common in females, patients with lower education and patients with positive result of IgG (p-value was respectively 0.002, 0.013, 0.010).
CONCLUSION
As a result of this study, Helicobacter pylori exposure, may could play a protective role against inflammatory bowel disease.
背景
幽门螺杆菌在炎症性肠病中的作用存在争议。本研究最初的理论是幽门螺杆菌是炎症性肠病的一个风险因素。在本研究中，我们调查了幽门螺杆菌感染与炎症性肠病的相关性。
方法
本病例对照研究在巴博尔的教学医院进行；60例新诊断的炎症性肠病患者，未接受任何幽门螺杆菌根除治疗，120例对照患者活检无炎症性肠病证据，通过IgA和IgG ELISA检测来调查幽门螺杆菌感染情况。使用SPSS 18.0版对临床信息、人口统计学和ELISA检测结果进行分析（显著性水平小于0.05）。
结果
病例组的平均年龄为42.27±13.64岁；对照组为45.52±13.83岁。在以下亚组的IgG研究中，病例组和对照组之间存在显著差异：30岁以下、女性、男性、城市居民、高等教育水平以及BMI在18.5至24.9之间（p值分别为；0.004、0.014、0.047、0.002、0.013、0.003）。基于逻辑回归分析；炎症性肠病在女性、低学历患者和IgG检测呈阳性的患者中不太常见（p值分别为0.002、0.013、0.010）。
结论
本研究结果表明，幽门螺杆菌感染可能对炎症性肠病起到保护作用。
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