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洛哌丁胺过量

Loperamide Overdose.

作者信息

Arnold Casey, Martinez Martinez Carmen J

机构信息

Emergency Medicine, Advent Health Florida Hospital, Orlando, USA.

出版信息

Cureus. 2019 May 25;11(5):e4753. doi: 10.7759/cureus.4753.

DOI:10.7759/cureus.4753
PMID:31363435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6663275/
Abstract

In light of the opioid epidemic, cardiac complications following a loperamide overdose are a growing concern for patients presenting to the emergency department (ED). Here, we present the case of a 35-year-old male with long QT syndrome who presented following a loperamide overdose and was receiving multiple shocks because of the resulting arrhythmias and electrolyte disturbances. It is necessary for emergency physicians to be aware of loperamide overdoses because cases have been increasing over the past several years and the cardiac complications can be life-threatening.

摘要

鉴于阿片类药物流行，洛哌丁胺过量后的心脏并发症日益引起急诊科就诊患者的关注。在此，我们报告一例35岁患有长QT综合征的男性患者，该患者因洛哌丁胺过量就诊，因由此导致的心律失常和电解质紊乱而接受多次电击治疗。急诊医生有必要了解洛哌丁胺过量情况，因为在过去几年中此类病例一直在增加，且心脏并发症可能危及生命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/1e2ab426b743/cureus-0011-00000004753-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/c4a9b67506c4/cureus-0011-00000004753-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/91ed95ea0b57/cureus-0011-00000004753-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/d36e5518abc9/cureus-0011-00000004753-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/1e2ab426b743/cureus-0011-00000004753-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/c4a9b67506c4/cureus-0011-00000004753-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/91ed95ea0b57/cureus-0011-00000004753-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/d36e5518abc9/cureus-0011-00000004753-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/6663275/1e2ab426b743/cureus-0011-00000004753-i04.jpg

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本文引用的文献

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U.S. Emergency Department Visits Resulting From Nonmedical Use of Pharmaceuticals, 2016.美国 2016 年因非医疗目的使用药品而导致的急诊就诊情况。
Am J Prev Med. 2019 May;56(5):639-647. doi: 10.1016/j.amepre.2018.12.009. Epub 2019 Mar 6.
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Clinical Review: Loperamide Toxicity.临床综述：洛哌丁胺毒性。
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Intentional Misuse and Abuse of Loperamide: A New Look at a Drug with "Low Abuse Potential".洛哌丁胺的故意误用与滥用：重新审视一种“低滥用潜力”药物
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Loperamide misuse and abuse.洛哌丁胺的误用与滥用。
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Loperamide Trends in Abuse and Misuse Over 13 Years: 2002-2015.洛哌丁胺13年（2002 - 2015年）的滥用和误用趋势
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Loperamide Induced Life Threatening Ventricular Arrhythmia.洛哌丁胺诱发危及生命的室性心律失常。
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Activated charcoal for acute overdose: a reappraisal.活性炭用于急性药物过量：重新评估
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Ventricular tachycardia associated with high-dose chronic loperamide use.与大剂量长期使用洛哌丁胺相关的室性心动过速。
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