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一名接触农药的农业工人患多发性骨髓瘤

Multiple Myeloma in an Agricultural Worker Exposed to Pesticides.

作者信息

Packard Elizabeth, Shahid Zainab, Groff Andrew, Patel Ravi, Jain Rohit

机构信息

Internal Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.

Internal Medicine, Lake Erie College of Osteopathic Medicine, Erie, USA.

出版信息

Cureus. 2019 May 28;11(5):e4762. doi: 10.7759/cureus.4762.

Abstract

Multiple myeloma (MM) is a neoplastic disorder characterized by the monoclonal proliferation of plasma cells in the bone marrow. It is estimated to account for only 1% of neoplastic diseases, and there is still a great deal of uncertainty about its precise etiology. Common risk factors with a proven association with MM include ionizing radiation exposure, age greater than 65, male gender, and the presence of monoclonal gammopathy of unknown significance (MGUS).More recently, research has shown that occupational exposures to pesticides also have a significant association with the development of MM. We present the case of an adult male who presented with rib pain, back pain, fevers, and progressive shortness of breath and was ultimately found to have multiple myeloma thought to be associated with occupational exposure to the pesticide captan.

摘要

多发性骨髓瘤(MM)是一种肿瘤性疾病,其特征为骨髓中浆细胞的单克隆增殖。据估计,它仅占肿瘤性疾病的1%,其确切病因仍存在很大不确定性。已证实与MM相关的常见风险因素包括电离辐射暴露、年龄大于65岁、男性以及意义未明的单克隆丙种球蛋白病(MGUS)。最近,研究表明职业性接触杀虫剂也与MM的发生有显著关联。我们报告一例成年男性病例,该患者出现肋骨疼痛、背痛、发热和进行性气短,最终被诊断为多发性骨髓瘤,认为与职业性接触杀虫剂克菌丹有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0614/6663119/e7e0a16dc175/cureus-0011-00000004762-i01.jpg

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