Moon Mi Sun, Quinn Gabriella, Townsend Elizabeth C, Ali Rabab O, Zhang Grace Y, Bradshaw Alyson, Hill Kareen, Guan Hannah, Hamilton Destanee, Kleiner David E, Koh Christopher, Heller Theo
Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz255.
Hepatitis C virus (HCV) infects 71 million individuals, and barriers to treatment remain. Bacterial translocation is a complication of chronic HCV infection, and this study evaluated circulating microbial components including lipopolysaccharide, peptidoglycan, and β-D-glucan in addition to their pattern recognition receptors and degree of hepatic macrophage uptake. The findings suggest that regulation of serum peptidoglycan and β-D-glucan differs from that of lipopolysaccharide. Additionally, macrophage activation in the liver may be better reflected by the degree of macrophage uptake than by circulating levels of microbial markers. These findings allow for a greater understanding of bacterial translocation and host immune activation during HCV infection.
丙型肝炎病毒（HCV）感染了7100万人，治疗障碍依然存在。细菌易位是慢性HCV感染的一种并发症，本研究评估了循环中的微生物成分，包括脂多糖、肽聚糖和β-D-葡聚糖，以及它们的模式识别受体和肝巨噬细胞摄取程度。研究结果表明，血清肽聚糖和β-D-葡聚糖的调节与脂多糖不同。此外，肝脏中巨噬细胞的激活可能通过巨噬细胞摄取程度比通过微生物标志物的循环水平能得到更好的反映。这些发现有助于更深入地了解HCV感染期间的细菌易位和宿主免疫激活。
