慢性丙型肝炎感染中的细菌易位与宿主免疫激活
Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection.
作者信息
Moon Mi Sun, Quinn Gabriella, Townsend Elizabeth C, Ali Rabab O, Zhang Grace Y, Bradshaw Alyson, Hill Kareen, Guan Hannah, Hamilton Destanee, Kleiner David E, Koh Christopher, Heller Theo
机构信息
Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
出版信息
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz255.
Abstract
Hepatitis C virus (HCV) infects 71 million individuals, and barriers to treatment remain. Bacterial translocation is a complication of chronic HCV infection, and this study evaluated circulating microbial components including lipopolysaccharide, peptidoglycan, and β-D-glucan in addition to their pattern recognition receptors and degree of hepatic macrophage uptake. The findings suggest that regulation of serum peptidoglycan and β-D-glucan differs from that of lipopolysaccharide. Additionally, macrophage activation in the liver may be better reflected by the degree of macrophage uptake than by circulating levels of microbial markers. These findings allow for a greater understanding of bacterial translocation and host immune activation during HCV infection.
摘要
丙型肝炎病毒（HCV）感染了7100万人，治疗障碍依然存在。细菌易位是慢性HCV感染的一种并发症，本研究评估了循环中的微生物成分，包括脂多糖、肽聚糖和β-D-葡聚糖，以及它们的模式识别受体和肝巨噬细胞摄取程度。研究结果表明，血清肽聚糖和β-D-葡聚糖的调节与脂多糖不同。此外，肝脏中巨噬细胞的激活可能通过巨噬细胞摄取程度比通过微生物标志物的循环水平能得到更好的反映。这些发现有助于更深入地了解HCV感染期间的细菌易位和宿主免疫激活。
相似文献
1
Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection.慢性丙型肝炎感染中的细菌易位与宿主免疫激活
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz255.
2
Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection.HIV感染、HCV感染及HIV/HCV合并感染中的肝纤维化、微生物易位和免疫激活标志物
Dig Liver Dis. 2015 Mar;47(3):218-25. doi: 10.1016/j.dld.2014.11.012. Epub 2014 Nov 29.
3
Role of microbial translocation in soluble CD14 up-regulation in HIV-, but not in HCV-, infected chimpanzees.微生物易位在HIV感染而非HCV感染的黑猩猩可溶性CD14上调中的作用。
J Gen Virol. 2016 Oct;97(10):2599-2607. doi: 10.1099/jgv.0.000577. Epub 2016 Aug 16.
4
Contribution of Liver Fibrosis and Microbial Translocation to Immune Activation in Persons Infected With HIV and/or Hepatitis C Virus.肝纤维化和微生物易位对感染 HIV 和/或丙型肝炎病毒者免疫激活的影响。
J Infect Dis. 2018 Mar 28;217(8):1289-1297. doi: 10.1093/infdis/jix688.
5
Eradication of Hepatitis C Virus (HCV) Reduces Immune Activation, Microbial Translocation, and the HIV DNA Level in HIV/HCV-Coinfected Patients.抗 HCV 治疗可降低 HIV/HCV 共感染患者的免疫激活、微生物易位和 HIV DNA 水平。
J Infect Dis. 2018 Jul 13;218(4):624-632. doi: 10.1093/infdis/jiy136.
6
HIV and hepatitis C coinfection: pathogenesis and microbial translocation.HIV 和丙型肝炎合并感染：发病机制和微生物易位。
Curr Opin HIV AIDS. 2011 Nov;6(6):472-7. doi: 10.1097/COH.0b013e32834bbc71.
7
Immune activation response in chronic HIV-infected patients: influence of Hepatitis C virus coinfection.慢性HIV感染患者的免疫激活反应：丙型肝炎病毒合并感染的影响。
PLoS One. 2015 Mar 16;10(3):e0119568. doi: 10.1371/journal.pone.0119568. eCollection 2015.
8
Chronic hepatitis C infection-induced liver fibrogenesis is associated with M2 macrophage activation.慢性丙型肝炎感染诱导的肝纤维化与 M2 巨噬细胞激活有关。
Sci Rep. 2016 Dec 21;6:39520. doi: 10.1038/srep39520.
9
Elevated liver stiffness is linked to increased biomarkers of inflammation and immune activation in HIV/hepatitis C virus-coinfected patients.肝硬度升高与 HIV/丙型肝炎病毒合并感染患者的炎症和免疫激活生物标志物升高有关。
AIDS. 2018 Jun 1;32(9):1095-1105. doi: 10.1097/QAD.0000000000001787.
10
Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo.表达最低限度人源化CD81和紧密连接蛋白基因的小鼠在体内支持丙型肝炎病毒摄取。
J Virol. 2017 Jan 31;91(4). doi: 10.1128/JVI.01799-16. Print 2017 Feb 15.
引用本文的文献
1
Intestinal flora of hepatitis C after direct antiviral drug therapy: A review.直接抗病毒药物治疗后丙型肝炎的肠道菌群：综述
Medicine (Baltimore). 2025 Aug 1;104(31):e42301. doi: 10.1097/MD.0000000000042301.
2
Fungal translocation measured by serum 1,3-ß-D-glucan correlates with severity and outcome of liver cirrhosis-A pilot study.血清 1,3-β-D-葡聚糖检测真菌易位与肝硬化严重程度和预后的相关性：一项初步研究。
Liver Int. 2023 Sep;43(9):1975-1983. doi: 10.1111/liv.15648. Epub 2023 Jun 19.
3
Biomarkers of gut barrier dysfunction and risk of hepatocellular carcinoma in the REVEAL-HBV and REVEAL-HCV cohort studies.肠道屏障功能障碍的生物标志物与 REVEAL-HBV 和 REVEAL-HCV 队列研究中肝细胞癌的风险。
Int J Cancer. 2023 Jul 1;153(1):44-53. doi: 10.1002/ijc.34492. Epub 2023 Mar 25.
4
Fungal infections and the fungal microbiome in hepatobiliary disorders.肝胆疾病中的真菌感染和真菌微生物组。
J Hepatol. 2023 Apr;78(4):836-851. doi: 10.1016/j.jhep.2022.12.006. Epub 2022 Dec 22.
5
Overview of the microbiota in the gut-liver axis in viral B and C hepatitis.肠道-肝脏轴中病毒 B、C 肝炎相关微生物组概述。
World J Gastroenterol. 2021 Nov 21;27(43):7446-7461. doi: 10.3748/wjg.v27.i43.7446.
6
Cannabis and Inflammation in HIV: A Review of Human and Animal Studies.大麻与 HIV 中的炎症：人类与动物研究综述。
Viruses. 2021 Aug 2;13(8):1521. doi: 10.3390/v13081521.
7
Gut Leakage of Fungal-Related Products: Turning Up the Heat for HIV Infection.肠道真菌相关产物渗漏：HIV 感染的“升温”因素。
Front Immunol. 2021 Apr 12;12:656414. doi: 10.3389/fimmu.2021.656414. eCollection 2021.
8
Improvement of Gut Diversity and Composition After Direct-Acting Antivirals in Hepatitis C Virus-Infected Patients With or Without Human Immunodeficiency Virus Coinfection.直接作用抗病毒药物治疗丙型肝炎病毒感染患者的肠道多样性和组成的改善：有无人类免疫缺陷病毒合并感染。
J Infect Dis. 2021 Oct 28;224(8):1410-1421. doi: 10.1093/infdis/jiab094.
9
Specificity Influences in (1→3)-β-d-Glucan-Supported Diagnosis of Invasive Fungal Disease.特异性对（1→3）-β-D-葡聚糖在侵袭性真菌病诊断中的影响
J Fungi (Basel). 2020 Dec 29;7(1):14. doi: 10.3390/jof7010014.
10
Glucan rich nutrition does not increase gut translocation of beta-glucan.富含葡聚糖的营养物质并不会增加β-葡聚糖的肠道易位。
Mycoses. 2021 Jan;64(1):24-29. doi: 10.1111/myc.13161. Epub 2020 Nov 21.
本文引用的文献
1
Rapid and persistent decline in soluble CD163 with successful direct-acting antiviral therapy and associations with chronic hepatitis C histology.直接抗病毒治疗成功后可溶性CD163的快速持续下降及其与丙型肝炎组织学的关联
Scand J Gastroenterol. 2018 Aug;53(8):986-993. doi: 10.1080/00365521.2018.1481996. Epub 2018 Jul 10.
2
Gastrointestinal Leakage Detected by Serum (1→3)-β-D-Glucan in Mouse Models and a Pilot Study in Patients with Sepsis.血清（1→3）-β-D-葡聚糖检测小鼠模型中的胃肠道渗漏及脓毒症患者的初步研究
Shock. 2016 Nov;46(5):506-518. doi: 10.1097/SHK.0000000000000645.
3
Hepatic macrophage activation and the LPS pathway in patients with alcoholic hepatitis: a prospective cohort study.酒精性肝炎患者的肝巨噬细胞激活和 LPS 途径：一项前瞻性队列研究。
Am J Gastroenterol. 2014 Nov;109(11):1749-56. doi: 10.1038/ajg.2014.262. Epub 2014 Aug 26.
4
The mycobiota: interactions between commensal fungi and the host immune system.真菌群：共生真菌与宿主免疫系统的相互作用。
Nat Rev Immunol. 2014 Jun;14(6):405-16. doi: 10.1038/nri3684.
5
Soluble CD163, a marker of Kupffer cell activation, is related to portal hypertension in patients with liver cirrhosis.可溶性 CD163，一种枯否细胞活化的标志物，与肝硬化患者的门脉高压有关。
Aliment Pharmacol Ther. 2012 Jul;36(2):173-80. doi: 10.1111/j.1365-2036.2012.05134.x. Epub 2012 May 16.
6
Accessory molecules for Toll-like receptors and their function. toll 样受体的辅助分子及其功能。
Nat Rev Immunol. 2012 Feb 3;12(3):168-79. doi: 10.1038/nri3151.
7
Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection.宿主对移位微生物产物的反应可预测 HBV 或 HCV 感染患者的结局。
Gastroenterology. 2011 Oct;141(4):1220-30, 1230.e1-3. doi: 10.1053/j.gastro.2011.06.063. Epub 2011 Jul 2.
8
Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS.枯否细胞在肝硬化门脉高压时被激活，而 TIPS 并不能使其正常化。
Gut. 2011 Oct;60(10):1389-93. doi: 10.1136/gut.2010.234542. Epub 2011 May 14.
9
Enterotypes of the human gut microbiome.人类肠道微生物组的肠型。
Nature. 2011 May 12;473(7346):174-80. doi: 10.1038/nature09944. Epub 2011 Apr 20.
10
Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection.病毒和宿主因素在慢性丙型肝炎病毒感染中诱导巨噬细胞活化和Toll样受体耐受性丧失。
Gastroenterology. 2007 Nov;133(5):1627-36. doi: 10.1053/j.gastro.2007.08.003. Epub 2007 Aug 2.
Zotero 插件