真菌群：共生真菌与宿主免疫系统的相互作用。
The mycobiota: interactions between commensal fungi and the host immune system.
机构信息
F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048, USA.
出版信息
Nat Rev Immunol. 2014 Jun;14(6):405-16. doi: 10.1038/nri3684.
Abstract
The body is host to a wide variety of microbial communities from which the immune system protects us and that are important for the normal development of the immune system and for the maintenance of healthy tissues and physiological processes. Investigators have mostly focused on the bacterial members of these communities, but fungi are increasingly being recognized to have a role in defining these communities and to interact with immune cells. In this Review, we discuss what is currently known about the makeup of fungal communities in the body and the features of the immune system that are particularly important for interacting with fungi at these sites.
摘要
人体是一个拥有多种微生物群落的宿主，免疫系统可以保护我们免受这些微生物的侵害，而这些微生物对免疫系统的正常发育以及维持健康的组织和生理过程都非常重要。研究人员主要关注这些群落中的细菌成员，但现在人们越来越认识到真菌在确定这些群落以及与免疫细胞相互作用方面也具有重要作用。在这篇综述中，我们讨论了目前已知的人体真菌群落的组成，以及免疫系统的哪些特征对于在这些部位与真菌相互作用特别重要。
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