Marshall Kalie R, Walton Stuart A, Boyd Megan, Bishop Bradley, Wellehan James, Craft William, Santoro Domenico
Department of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, PO Box 100126, Gainesville, FL, 32611, USA.
Department of Comparative, Diagnostic and Population Medicine College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, PO Box 100126, Gainesville, FL, 32611, USA.
Vet Dermatol. 2019 Oct;30(5):434-e134. doi: 10.1111/vde.12773. Epub 2019 Jul 31.
Erysipelothrix rhusiopathiae is a widespread Gram-positive, nonsporulating rod bacterium predominantly associated with skin disease in swine and cetaceans. Cutaneous lesions have yet to be described in dogs.
To describe the clinical presentation, molecular and histopathological diagnosis, and treatment of a case of erysipeloid caused by E. rhusiopathiae in a dog.
A 6-month-old spayed female standard poodle dog presented with lethargy, fever, vomiting and diarrhoea. Skin lesions appeared 20 days post first examination.
Complete blood count, serum chemistry profile, urinalysis, urine culture, blood culture, computed topography, forelimb radiography, joint and cerebrospinal fluid aspiration were performed; samples were collected for skin cytological evaluation, culture and histopathological analysis.
Blood cultures yielded Gram-positive, catalase-negative bacilli. Histopathological evaluation of skin biopsies revealed lymphoplasmacytic, neutrophilic and histiocytic perivascular and periadnexal dermatitis, and vasculitis. Cutaneous and blood PCR and sequencing of 16S rRNA identified the bacteria as E. rhusiopathiae. Clinical resolution was observed following the use of of amoxicillin/clavulanic acid and ciprofloxacin therapies.
To the best of the authors' knowledge, this is the first confirmed case of erysipeloid caused by E. rhusiopathiae in a dog. Clinical resolution was attained with the extended use of antibiotics. After 13 months, no clinical signs had returned.
猪红斑丹毒丝菌是一种广泛存在的革兰氏阳性、无芽孢杆菌，主要与猪和鲸类的皮肤病有关。犬类的皮肤病变尚未见报道。
描述一例犬感染猪红斑丹毒丝菌引起的类丹毒的临床表现、分子和组织病理学诊断及治疗情况。
一只6月龄已绝育的雌性标准贵宾犬，表现为嗜睡、发热、呕吐和腹泻。首次检查20天后出现皮肤病变。
进行了全血细胞计数、血清生化检查、尿液分析、尿培养、血培养、计算机断层扫描、前肢X线摄影、关节和脑脊液穿刺；采集样本进行皮肤细胞学评估、培养及组织病理学分析。
血培养分离出革兰氏阳性、过氧化氢酶阴性杆菌。皮肤活检的组织病理学评估显示淋巴细胞浆细胞性、中性粒细胞性和组织细胞性血管周围及腺周皮炎，以及血管炎。皮肤和血液PCR及16S rRNA测序鉴定该细菌为猪红斑丹毒丝菌。使用阿莫西林/克拉维酸和环丙沙星治疗后观察到临床症状缓解。
据作者所知，这是首例犬感染猪红斑丹毒丝菌引起类丹毒的确诊病例。延长使用抗生素后临床症状得到缓解。13个月后，未再出现临床症状。
