Jevtic Dragana, Djokic Dragomir, Redzic Danka, Aleksic Dragana, Parezanovic Miro, Pasic Srdjan
Departments of Hemato-Oncology II, Mother and Child Health Care Institute of Serbia, Radoja Dakica St., Belgrade, Serbia.
Mother and Child Health Care Institute of Serbia, Radoja Dakica St., Belgrade, Serbia.
Turk J Pediatr. 2018;60(6):735-738. doi: 10.24953/turkjped.2018.06.016.
Jevtic D, Djokic D, Redzic D, Aleksic D, Parezanovic M, Pasic S. Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report. Turk J Pediatr 2018; 60: 735-738. Leptospirosis caused by spirochetes of the genus Leptospira in most patients result in very mild illness without jaundice. However, a small portion of patients develop various complications due to the involvement of multiple organ systems. Hemophagocytic lymphohistiocytosis is characterized by prolonged fever, hepatosplenomegaly and cytopenias, hyperferritinemia and hypertriglyceridemias, hyperfibrinogenemia, and hemophagocytosis in bone marrow, lymph nodes, spleen, or liver. Hemophagocytic lymphohistiocytosis associated with leptospirosis is a very rare condition and it should be considered in patients with multiple organ dysfunctions, together with adequate laboratory findings. It can delay the correct diagnosis of leptospirosis and contribute to an adverse outcome. We present a 13-year-old girl with secondary hemophagocytic lymphohistiocytosis caused by leptospira infection and favorable outcome with appropriate antibiotics and corticosteroid therapy.
耶夫蒂奇D、乔基奇D、雷齐奇D、亚历克西奇D、帕雷扎诺维奇M、帕西奇S。一名钩端螺旋体感染儿童的继发性噬血细胞性淋巴组织细胞增生症：病例报告。《土耳其儿科学杂志》2018年；60：735 - 738。大多数由钩端螺旋体属螺旋体引起的钩端螺旋体病导致非常轻微的疾病且无黄疸。然而，一小部分患者由于多个器官系统受累而出现各种并发症。噬血细胞性淋巴组织细胞增生症的特征为持续发热、肝脾肿大和血细胞减少、高铁蛋白血症和高甘油三酯血症、高纤维蛋白原血症以及骨髓、淋巴结、脾脏或肝脏中的噬血细胞现象。与钩端螺旋体病相关的噬血细胞性淋巴组织细胞增生症是一种非常罕见的病症，对于出现多器官功能障碍且有适当实验室检查结果的患者应予以考虑。它可能会延迟钩端螺旋体病的正确诊断并导致不良后果。我们报告一名13岁女孩，她因钩端螺旋体感染导致继发性噬血细胞性淋巴组织细胞增生症，经适当的抗生素和皮质类固醇治疗后预后良好。
