Department of Psychiatry, Shimane University, 89-1 Enya-cho, Izumo 693-8501, Japan.
Health Service Center, Kochi University, 2-5-1 Akebono-cho, Kochi 780-8520, Japan.
Int J Mol Sci. 2019 Jul 30;20(15):3723. doi: 10.3390/ijms20153723.
Increasing evidence implies a possible causal link between periodontitis and neuropsychiatric disorders, such as Alzheimer's disease (AD) and major depression (MD). A possible mechanism underlying such a link can be explained by neuroinflammation induced by chronic systemic inflammation. This review article focuses on an overview of the biological and epidemiological evidence for a feasible causal link of periodontitis to neuropsychiatric disorders, including AD, MD, Parkinson's disease, and schizophrenia, as well as the neurological event, ischemic stroke. If there is such a link, a broad spectrum of neuropsychiatric disorders associated with neuroinflammation could be preventable and modifiable by simple daily dealings for oral hygiene. However, the notion that periodontitis is a risk factor for neuropsychiatric disorders remains to be effectively substantiated.
越来越多的证据表明，牙周炎与神经精神疾病之间可能存在因果关系，例如阿尔茨海默病（AD）和重度抑郁症（MD）。这种联系的一个可能机制可以通过慢性全身炎症引起的神经炎症来解释。本文综述了牙周炎与神经精神疾病（包括 AD、MD、帕金森病和精神分裂症）以及神经事件（缺血性中风）之间可能存在因果关系的生物学和流行病学证据。如果存在这种联系，那么与神经炎症相关的广泛的神经精神疾病可以通过简单的日常口腔卫生来预防和改善。然而，牙周炎是神经精神疾病的危险因素这一观点仍有待有效证实。
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