Lee Na-Eun, Yoo Dae Myoung, Han Kyeong Min, Kang Ho Suk, Kim Ji Hee, Kim Joo-Hee, Bang Woo Jin, Choi Hyo Geun, Kim Nan Young, Park Ha Young, Kwon Mi Jung
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Laboratory of Brain and Cognitive Sciences for Convergence Medicine, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Biomedicines. 2024 Apr 3;12(4):792. doi: 10.3390/biomedicines12040792.
Recent research suggests a potential relevance between chronic periodontitis (CP) and Parkinson's disease (PD), raising concerns about comorbid PD among elderly CP patients. However, the epidemiologic basis for this association remains unclear. Employing a nested case-control design, this study explored the association between CP and subsequent PD occurrences in Korean adults, leveraging a validated national population-based dataset covering the period from 2002 to 2019. It included 8794 PD patients and 35,176 matched control individuals, established through propensity score matching for age, sex, residential area, and income. Baseline characteristics were compared using standardized differences, and logistic regression was employed to assess the impact of CP histories on PD likelihood while controlling for covariates. We performed a thorough examination of CP events within both 1-year and 2-year intervals preceding the index date, incorporating subgroup analyses. Our analysis revealed no statistically significant association between CP history and PD development overall. However, subgroup analysis revealed a slightly increased likelihood of PD development among CP individuals with a high disease burden (Charlson Comorbidity Index score ≥ 2). In conclusion, although our study did not find a significant overall association between CP history and PD development, the elevated likelihood of PD in subgroups with high disease burden may suggest that comorbidities influence PD probability among certain CP patients. Considering comorbid conditions in PD screening for some individuals with CP may be also important.
近期研究表明慢性牙周炎（CP）与帕金森病（PD）之间可能存在关联，这引发了对老年CP患者中合并PD的担忧。然而，这种关联的流行病学基础仍不清楚。本研究采用巢式病例对照设计，利用一个经过验证的基于全国人口的数据集（涵盖2002年至2019年），探讨了韩国成年人中CP与随后发生PD之间的关联。研究纳入了8794例PD患者和35176例匹配的对照个体，通过年龄、性别、居住地区和收入的倾向得分匹配确定。使用标准化差异比较基线特征，并采用逻辑回归评估CP病史对PD发生可能性的影响，同时控制协变量。我们对索引日期前1年和2年期间内的CP事件进行了全面检查，并进行了亚组分析。我们的分析显示，总体而言，CP病史与PD发展之间没有统计学上的显著关联。然而，亚组分析显示，疾病负担较高（查尔森合并症指数评分≥2）的CP个体发生PD的可能性略有增加。总之，尽管我们的研究未发现CP病史与PD发展之间存在显著的总体关联，但疾病负担高的亚组中PD发生可能性升高可能表明合并症会影响某些CP患者发生PD的概率。对于一些CP患者，在PD筛查中考虑合并症情况可能也很重要。
