Departments of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan 8715988141, Iran.
Department of Radiology, Faculty of Paramedical, Tehran University of Medical Sciences, Tehran 1416753955, Iran.
Medicina (Kaunas). 2019 Jul 30;55(8):417. doi: 10.3390/medicina55080417.
Pneumonitis and fibrosis are the most common consequences of lung exposure to a high dose of ionizing radiation during an accidental radiological or nuclear event, and may lead to death, after some months to years. So far, some anti-inflammatory and antioxidant agents have been used for mitigation of lung injury. In the present study, we aimed to detect possible mitigatory effects of melatonin and metformin on radiation-induced pneumonitis and lung fibrosis. 40 male mice were divided into 4 groups (10 mice in each). For control group, mice did not receive radiation or drugs. In group 2, mice were irradiated to chest area with 18 Gy gamma rays. In groups 3 and 4, mice were first irradiated similar to group 2. After 24 h, treatment with melatonin as well as metformin began. Mice were sacrificed after 100 days for determination of mitigation of lung pneumonitis and fibrosis by melatonin or metformin. Results showed that both melatonin and metformin are able to mitigate pneumonitis and fibrosis markers such as infiltration of inflammatory cells, edema, vascular and alveolar thickening, as well as collagen deposition. Melatonin and metformin may have some interesting properties for mitigation of radiation pneumonitis and fibrosis after an accidental radiation event.
放射性肺炎和肺纤维化是意外放射性或核事件中肺部暴露于高剂量电离辐射的最常见后果，可能在数月至数年后导致死亡。到目前为止，一些抗炎和抗氧化剂已被用于减轻肺损伤。在本研究中，我们旨在检测褪黑素和二甲双胍对放射性肺炎和肺纤维化的可能缓解作用。40 只雄性小鼠被分为 4 组（每组 10 只）。对于对照组，小鼠未接受辐射或药物治疗。在第 2 组中，用 18 Gy γ射线照射小鼠胸部。在第 3 组和第 4 组中，小鼠首先像第 2 组一样接受辐射。24 小时后，开始用褪黑素和二甲双胍进行治疗。100 天后处死小鼠，通过褪黑素或二甲双胍确定对肺肺炎和纤维化的缓解作用。结果表明，褪黑素和二甲双胍均能减轻炎症细胞浸润、水肿、血管和肺泡增厚以及胶原蛋白沉积等肺炎和纤维化标志物。褪黑素和二甲双胍可能具有一些有趣的特性，可用于缓解意外辐射事件后的放射性肺炎和纤维化。
