Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.
Department of Oncology, Leuven Cancer Institute, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, Catholic University of Leuven, Leuven, Belgium.
Anticancer Res. 2019 Aug;39(8):3981-3989. doi: 10.21873/anticanres.13553.
Uterine sarcomas are rare but very aggressive. Uterine myomas, on the other hand, are the most common benign tumors of the uterus. Currently there is no diagnostic technique available to distinguish them with certainty. This study aimed to summarize the published literature concerning protein-based biomarkers in the peripheral blood that can assist in this difficult differential diagnosis. In total, 48 articles, published between 1990 and 2017, were included. Most studies (n=37) concerned soft tissue sarcomas, while 11 discussed uterine sarcomas specifically. Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), interleukins (IL), cancer antigen 125 (CA 125), lactate dehydrogenase, gangliosides (LDH) and growth differentiation factor 15 (GDF-15) are the most studied proteins in soft tissue sarcomas, including uterine sarcomas. Future research on improving sarcoma diagnosis should include these proteins.
子宫肉瘤较为罕见，但侵袭性很强。另一方面，子宫肌瘤是子宫最常见的良性肿瘤。目前尚无确切的诊断技术可以将它们区分开来。本研究旨在总结关于外周血中蛋白质生物标志物的已发表文献，这些标志物可辅助这一困难的鉴别诊断。共纳入 1990 年至 2017 年间发表的 48 篇文章。大多数研究（n=37）涉及软组织肉瘤，而 11 篇专门讨论了子宫肉瘤。血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）、白细胞介素（IL）、癌抗原 125（CA 125）、乳酸脱氢酶、神经节苷脂（LDH）和生长分化因子 15（GDF-15）是软组织肉瘤中（包括子宫肉瘤）研究最多的蛋白。未来关于提高肉瘤诊断的研究应包括这些蛋白。
