麝香葡萄提取物对不同种族三阴性乳腺癌细胞的抗癌和抗氧化作用。
The Anticancer and Antioxidant Effects of Muscadine Grape Extracts on Racially Different Triple-negative Breast Cancer Cells.
机构信息
College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, U.S.A.
Center for Viticulture & Small Fruit Research, College of Agriculture & Food Sciences, Florida A&M University, Tallahassee, FL, U.S.A.
出版信息
Anticancer Res. 2019 Aug;39(8):4043-4053. doi: 10.21873/anticanres.13560.
Abstract
BACKGROUND/AIM: Triple-negative breast cancer (TNBC) is the most aggressive subtype, predominant in African American women. In this study, the antioxidant/anticancer activity of muscadine grape extracts and the role of their phenolic and flavonoid contents in exerting these properties were investigated in TNBC cells.
MATERIALS AND METHODS
Berry extracts from muscadine genotypes were investigated for total phenolic content (TPC), total flavonoid content (TFC), antioxidant capacity, and anticancer effects using breast cancer cell lines, representing Caucasians and African Americans.
RESULTS
The antioxidant activity was associated with high TPC content. Extracts showed cytotoxicity up to 78.6% in Caucasians and 90.7% in African American cells, with an association with high antioxidant capacity. There was a strong correlation between TPC and anticancer/antioxidant activities.
CONCLUSION
The anticancer and antioxidant effects of muscadine grapes are attributed to the TPC of extracts, which showed a stronger positive correlation with growth inhibition of African American breast cancer cells compared to Caucasians.
摘要
背景/目的：三阴性乳腺癌（TNBC）是最具侵袭性的亚型，主要发生在非裔美国女性中。在这项研究中，研究了麝香葡萄提取物的抗氧化/抗癌活性及其酚类和类黄酮含量在发挥这些特性中的作用，用于 TNBC 细胞。
材料和方法
用来自麝香葡萄基因型的浆果提取物研究总酚含量（TPC）、总黄酮含量（TFC）、抗氧化能力和使用乳腺癌细胞系的抗癌作用，这些细胞系代表白人和非裔美国人。
结果
抗氧化活性与高 TPC 含量相关。提取物在白人和非裔美国人细胞中分别表现出高达 78.6%和 90.7%的细胞毒性，与高抗氧化能力相关。TPC 与抗癌/抗氧化活性之间存在很强的相关性。
结论
麝香葡萄的抗癌和抗氧化作用归因于提取物的 TPC，与白种人乳腺癌细胞相比，它与非裔美国人乳腺癌细胞的生长抑制具有更强的正相关性。
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