Fleming R, Haxton M J, Hamilton M P, Conaghan C J, Black W P, Yates R W, Coutts J R
University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, Scotland.
Am J Obstet Gynecol. 1988 Aug;159(2):376-81. doi: 10.1016/s0002-9378(88)80088-7.
The ovarian function of infertile women with normal menstrual rhythm was investigated by daily plasma hormone (estradiol, progesterone, luteinizing hormone, and follicle-stimulating hormone) analyses throughout the menstrual cycle, and patients were diagnosed as showing a subnormal profile of progesterone in the early luteal phase or as showing no abnormality. Women with oligomenorrhea and elevated luteinizing hormone levels were diagnosed as having polycystic ovary syndrome primarily on the basis of endocrinology. All patients were treated with a gonadotropin-releasing hormone analog to suppress endogenous luteinizing hormone and follicle-stimulating hormone so that ovulation induction with exogenous gonadotropins could be undertaken as in patients with hypogonadotropic hypogonadism. Interference in the process of ovulation by endogenous luteinizing hormone fluctuations was eliminated and pregnancies were achieved. The pregnancy rate in the group with polycystic ovary syndrome was 77% per treatment course (six cycles) while that in the group with subnormal progesterone profiles was 61.5%. Patients showing no abnormality achieved no pregnancy, demonstrating the redundancy of interference with normal ovarian function.
通过在整个月经周期中每日分析血浆激素（雌二醇、孕酮、促黄体生成素和促卵泡激素），对月经周期正常的不孕女性的卵巢功能进行了研究，患者被诊断为黄体期早期孕酮水平低于正常或无异常。月经稀发且促黄体生成素水平升高的女性主要根据内分泌学诊断为多囊卵巢综合征。所有患者均接受促性腺激素释放激素类似物治疗，以抑制内源性促黄体生成素和促卵泡激素，从而能够像低促性腺激素性性腺功能减退患者一样进行外源性促性腺激素诱导排卵。消除了内源性促黄体生成素波动对排卵过程的干扰并实现了妊娠。多囊卵巢综合征组每个治疗疗程（六个周期）的妊娠率为77%，而孕酮水平低于正常组为61.5%。无异常的患者未实现妊娠，这表明干扰正常卵巢功能是多余的。
