Fleming R, Adam A H, Barlow D H, Black W P, MacNaughton M C, Coutts J R
Br J Obstet Gynaecol. 1982 Jan;89(1):80-3. doi: 10.1111/j.1471-0528.1982.tb04642.x.
Five infertile women, with normal menstrual rhythm who had been investigated previously by daily hormone analyses throughout at least one complete menstrual cycle and had shown poor luteal-phase steroid-hormone profiles were treated by a new approach. They were rendered hypogonadotrophic with large doses of a luteinizing hormone releasing-hormone analogue (Hoe 766) and were then treated with exogenous gonadotrophins to induce follicular growth and ovulation. Progesterone production after ovulation in all cases was superior to that observed in the individual patients' without treatment. One patients conceived in her first conception cycle and another in her fourth. This regimen offers a systematic approach to the treatment of unexplained infertility in women with deficient luteal-phase steroid-hormone profiles.
五名月经周期正常的不孕女性，此前通过在至少一个完整月经周期内每日进行激素分析进行了检查，结果显示黄体期类固醇激素水平不佳，她们接受了一种新的治疗方法。她们先用大剂量的促黄体生成素释放激素类似物（Hoe 766）使促性腺激素分泌减少，然后用外源性促性腺激素治疗以诱导卵泡生长和排卵。所有病例排卵后的孕酮生成均优于未治疗的个体患者。一名患者在第一个受孕周期受孕，另一名在第四个受孕周期受孕。该方案为治疗黄体期类固醇激素水平不足的不明原因不孕女性提供了一种系统的方法。
