Alger L S, Lovchik J C, Hebel J R, Blackmon L R, Crenshaw M C
Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore 21201.
Am J Obstet Gynecol. 1988 Aug;159(2):397-404. doi: 10.1016/s0002-9378(88)80093-0.
There is conflicting evidence regarding a possible causal role for Chlamydia trachomatis in the development of preterm premature rupture of the membranes. We investigated the relative prevalence of endocervical infection with C. trachomatis and group B streptococci in patients with preterm premature rupture of membranes compared with a control group taken from the same obstetric population. C. trachomatis was isolated from 23/52 (44%) patients with preterm premature rupture of membranes versus 13/84 (15%) women in the control group (p less than 0.001). This association was independent of infection with group B streptococci or Neisseria gonorrhoeae. Group B streptococci were isolated from 16% of the patients with preterm premature rupture of membranes versus 4% of the control population (p less than 0.05). The risk of preterm premature rupture of membranes associated with group B streptococcal infection was independent of infection with C. trachomatis and N. gonorrhoeae. Endocervical infection with C. trachomatis did not significantly affect early maternal complication rates after delivery.
关于沙眼衣原体在胎膜早破发生中可能的因果作用，存在相互矛盾的证据。我们调查了胎膜早破患者与来自同一产科人群的对照组相比，沙眼衣原体和B族链球菌宫颈内感染的相对患病率。在52例胎膜早破患者中有23例（44%）分离出沙眼衣原体，而对照组84名女性中有13例（15%）分离出沙眼衣原体（p小于0.001）。这种关联独立于B族链球菌或淋病奈瑟菌感染。16%的胎膜早破患者分离出B族链球菌，而对照组人群为4%（p小于0.05）。与B族链球菌感染相关的胎膜早破风险独立于沙眼衣原体和淋病奈瑟菌感染。沙眼衣原体宫颈内感染对分娩后早期产妇并发症发生率没有显著影响。
