新辅助化疗增加食管鳞状细胞癌中PD-L1表达及CD8肿瘤浸润淋巴细胞
Neoadjuvant Chemotherapy Increases PD-L1 Expression and CD8 Tumor-infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma.
作者信息
Fukuoka Eiji, Yamashita Kimihiro, Tanaka Tomoko, Sawada Ryuichiro, Sugita Yutaka, Arimoto Akira, Fujita Mitsugu, Takiguchi Gosuke, Matsuda Takeru, Oshikiri Taro, Nakamura Tetsu, Suzuki Satoshi, Kakeji Yoshihiro
机构信息
Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
出版信息
Anticancer Res. 2019 Aug;39(8):4539-4548. doi: 10.21873/anticanres.13631.
BACKGROUND/AIM: The aim of this study was to investigate PD-L1 expression and its association with prognosis in esophageal squamous cell carcinoma (ESCC) before and after neoadjuvant chemotherapy (5-fluorouracil and cisplatin, NAC-FP).
PATIENTS AND METHODS
Using a database of 69 ESCC patients, we analyzed PD-L1 expression on tumor cells (TCs) and immune cells (ICs), as well as the density of CD8 tumor-infiltrating lymphocytes (TILs) in pretreatment biopsy specimens-versus-surgical specimens after resection. We determined the prognostic significance of these factors.
RESULTS
The fraction of ESCC containing ICs expressing PD-L1 and having a high CD8 TIL density was significantly increased after neoadjuvant treatment. However, PD-L1 expression on TCs or ICs, and CD8 TIL density, was not significantly associated with patient survival in ESCC patients.
CONCLUSION
NAC-FP induced PD-L1 expression on ICs and CD8 TILs in ESCC patients. This finding suggests that PD-1/PD-L1 blockade could be combined with NAC-FP to treat ESCC patients.
背景/目的：本研究旨在调查新辅助化疗（5-氟尿嘧啶和顺铂，NAC-FP）前后食管鳞状细胞癌（ESCC）中PD-L1的表达及其与预后的关系。
患者与方法
利用一个包含69例ESCC患者的数据库，我们分析了治疗前活检标本与切除后手术标本中肿瘤细胞（TCs）和免疫细胞（ICs）上的PD-L1表达，以及CD8肿瘤浸润淋巴细胞（TILs）的密度。我们确定了这些因素的预后意义。
结果
新辅助治疗后，含有表达PD-L1的ICs且CD8 TIL密度高的ESCC比例显著增加。然而，ESCC患者中TCs或ICs上的PD-L1表达以及CD8 TIL密度与患者生存率无显著相关性。
结论
NAC-FP诱导ESCC患者ICs和CD8 TILs上的PD-L1表达。这一发现表明，PD-1/PD-L1阻断可与NAC-FP联合用于治疗ESCC患者。
Zotero 插件