一例伴有肉瘤样变的巨大胰腺腺鳞癌：罕见病例报告
A huge adenosquamous carcinoma of the pancreas with sarcomatoid change: an unusual case report.
作者信息
Lu Bao-Chun, Wang Chen, Yu Jian-Hua, Shen Zhi-Hong, Yang Jian-Hui
机构信息
Bao-Chun Lu, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang, Department of General Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China.
出版信息
World J Gastroenterol. 2014 Nov 21;20(43):16381-6. doi: 10.3748/wjg.v20.i43.16381.
Abstract
Adenosquamous carcinoma rarely occurs in the pancreas, and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma. Here, we describe a rare case of pancreatic adenosquamous carcinoma with sarcomatous change. Immunohistochemistry showed that the sarcomatous lesion lost the epithelial marker and aberrantly expressed of acquired mesenchymal markers, which indicated that this special histological phenotype may be attributed to epithelial-mesenchymal transition. This case also indicated that a routine radical surgery without aggressive treatment strategies was still appropriate for adenosquamous carcinoma of the pancreas with sarcomatoid change.
摘要
腺鳞癌很少发生于胰腺，其特征是同时存在导管腺癌和鳞癌的细胞成分。在此，我们描述一例伴有肉瘤样变的胰腺腺鳞癌罕见病例。免疫组化显示肉瘤样病变失去上皮标志物并异常表达获得性间充质标志物，这表明这种特殊的组织学表型可能归因于上皮-间充质转化。该病例还表明，对于伴有肉瘤样变的胰腺腺鳞癌，常规根治性手术而不采取积极的治疗策略仍然是合适的。
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