Sakuta Kenichi, Mukai Taiji, Suzuki Kazuhito, Nishiwaki Kaichi, Yaguchi Hiroshi
Department of Neurology, Kashiwa Hospital, The Jikei University School of Medicine, Japan.
Department of Clinical Oncology/Hematology, Kashiwa Hospital, The Jikei University School of Medicine, Japan.
Intern Med. 2019 Dec 15;58(24):3573-3575. doi: 10.2169/internalmedicine.3279-19. Epub 2019 Jul 31.
A 48-year-old woman with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin change (POEMS) syndrome suddenly presented with numbness of her right upper limb. Magnetic resonance imaging showed multiple acute infarctions in her left cerebrum, and magnetic resonance angiography (MRA) showed multiple intra-cranial vascular lesions, which contrasted with previously normal MRA results obtained eight months prior to the stroke. After completing successful treatment for POEMS syndrome, there were no recurrent stroke episodes. A six-month follow-up scan showed that although the vascular lesions did not progress, they did not improve much either. POEMS syndrome is associated with the rapid extension of large blood vessels-vasculopathy-resulting in nearly irreversible brain lesions.
一名患有多神经病、器官肿大、内分泌病、M蛋白、皮肤改变（POEMS）综合征的48岁女性突然出现右上肢麻木。磁共振成像显示其左大脑有多处急性梗死，磁共振血管造影（MRA）显示有多处颅内血管病变，这与中风前八个月获得的正常MRA结果形成对比。成功完成POEMS综合征治疗后，未出现复发性中风发作。六个月的随访扫描显示，尽管血管病变没有进展，但也没有明显改善。POEMS综合征与大血管快速扩张——血管病变——导致几乎不可逆的脑损伤有关。
