Wada Takeshi
Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science.
Division of Academic Detailing Database, Research Institute of Science and Technology, Tokyo University of Science.
Yakugaku Zasshi. 2019;139(8):1101-1105. doi: 10.1248/yakushi.19-00003-6.
In order to implement academic detailing, it is extremely important to understand the pharmacological activity of drugs based on their chemical structures. To construct a database for academic detailing, a viewpoint for clinically utilizing the fundamental pharmacological features of a drug is required. These fundamental pharmacological features include chemical characteristics such as chemical structures, physical characteristics such as pharmaceutical formulations for efficient drug delivery to target organs, and a pharmacological viewpoint, which is a mechanism by which a drug is determined to be effective. In addition, in vivo kinetics are included in a drug's pharmacological features, i.e., a drug's excretion through urine and feces via the kidneys, its side effects due to differences in enzyme type when the drug is metabolized in the liver, as well as the capacity of the patient's current enzyme profile. This review describes academic detailing based on the chemical structure of drugs for breast cancer hormone therapy, as an example.
为了实施学术推广，基于药物的化学结构了解其药理活性极为重要。为构建学术推广数据库，需要一个从临床角度利用药物基本药理特性的观点。这些基本药理特性包括化学特征，如化学结构；物理特征，如用于将药物有效递送至靶器官的药物制剂；以及药理学观点，即确定药物有效性的机制。此外，药物的药理特性还包括体内动力学，即药物通过肾脏经尿液和粪便的排泄、药物在肝脏代谢时因酶类型差异产生的副作用，以及患者当前的酶谱情况。本综述以乳腺癌激素治疗药物的化学结构为例描述学术推广。
