Gynecologic Cancer Unit, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Department of Gynecology, Ordensklinikum Linz, Seilerstätte 4, 4020, Linz, Austria.
Sci Rep. 2019 Jul 31;9(1):11129. doi: 10.1038/s41598-019-47560-3.
Vulvar cancer is a rare malignancy with poor prognosis that generally occurs in elderly patients. The individual prognosis is difficult to assess. Serum creatinine levels are frequently elevated in elderly patients. Recent evidence have shown shown that - besides indicating kidney impairment - serum creatinine levels may be used to predict the survival in cancer patients. Several studies observed an association between elevated serum creatinine levels and poor prognosis in patients with solid tumors. In this retrospective cohort study, serum creatinine levels were evaluated in 170 patients with invasive vulvar cancer. Serum creatinine levels were correlated to established clinicopathologic factors. Univariate and multivariate survival analysis were performed. Elevated serum creatinine levels (>1.2 mg/dl) were significantly associated with both poor disease specific and overall survival. Three year overall survival rates were 74.8% and 32.5% for patients with serum creatinine levels of ≤ and >1.2 mg/dl, respectively. In a multivariate survival model, serum creatinine levels were significantly associated with overall survival independent of tumor stage and patients' age. In conclusion, pretherapeutic serum creatinine levels may be useful as an independent prognostic parameter in patients with vulvar cancer.
外阴癌是一种预后不良的罕见恶性肿瘤，通常发生在老年患者中。个体预后难以评估。老年患者的血清肌酐水平经常升高。最近的证据表明，除了表明肾脏损伤外，血清肌酐水平还可用于预测癌症患者的生存情况。几项研究观察到，在患有实体瘤的患者中，血清肌酐水平升高与预后不良之间存在关联。在这项回顾性队列研究中，评估了 170 例侵袭性外阴癌患者的血清肌酐水平。将血清肌酐水平与既定的临床病理因素相关联。进行了单变量和多变量生存分析。血清肌酐水平升高（>1.2mg/dl）与疾病特异性和总体生存率均显著相关。血清肌酐水平≤和>1.2mg/dl 的患者 3 年总生存率分别为 74.8%和 32.5%。在多变量生存模型中，血清肌酐水平与肿瘤分期和患者年龄无关，是总体生存率的独立预后因素。总之，治疗前的血清肌酐水平可作为外阴癌患者的独立预后参数。
