Arima S, Futami K, Shigeta M, Yoshimura S, Tateishi S, Shinohara T, Sakaida R
Dept. of Surgery, Chikushi Hospital, School of Medicine, Fukuoka University, Japan.
Gan To Kagaku Ryoho. 1988 Aug;15(8):2279-83.
Forty-one patients with advanced gastric cancer underwent gastrectomy, and the correlation between tissue uptake of the adjuvant drug and the prognosis were studied. The patients were preoperatively administered Tegafur and samples of tissue were obtained intraoperatively. 5-FU levels in the tumor and lymphnodes were measured by gas chromato-mass fragmentography (GCMF). The patients measured for 5-FU tissue uptake were given more than 60 g of tegafur as postoperative adjuvant chemotherapy, and divided into two groups; one in which the 5-FU uptake by tumor tissue and lymphnode was over 0.05 microgram/g and the other lower than 0.05 microgram/g. In both groups there were no significant differences in background factors. Each survival rate was calculated by the Kaplan-Meier method, and the generalized Wilcoxon method was used for statistical analysis. There was no statistically significant correlation between 5-FU uptake by the tumor and the prognosis, but the 5-year survival rate in the group with over 0.05 microgram/g uptake by lymphnodes was statistically significant (p = 0.018).
41例晚期胃癌患者接受了胃切除术，并研究了辅助药物的组织摄取与预后之间的相关性。患者术前给予替加氟，并在术中获取组织样本。通过气相色谱 - 质谱碎片分析法（GCMF）测量肿瘤和淋巴结中的5 - FU水平。对测量5 - FU组织摄取的患者给予超过60 g替加氟作为术后辅助化疗，并分为两组；一组肿瘤组织和淋巴结中5 - FU摄取量超过0.05微克/克，另一组低于0.05微克/克。两组的背景因素无显著差异。各生存率采用Kaplan - Meier法计算，采用广义Wilcoxon法进行统计分析。肿瘤中5 - FU摄取与预后之间无统计学显著相关性，但淋巴结摄取量超过0.05微克/克的组5年生存率具有统计学显著性（p = 0.018）。
