Reddy P Ravi Tejeshwar, Vandana K V, Prakash Shobha
Department of Periodontics, College of Dental Sciences, Davangere, Karnataka, India.
Ayu. 2018 Oct-Dec;39(4):226-229. doi: 10.4103/ayu.AYU_176_16.
commonly called as ( Forssk.) is a perennial herb that belongs to the family . A range of biological activities has been found from plant extracts, including wound healing activity, anti-inflammatory, analgesic, antioxidant, weak antibiotic, immunomodulating and anti-ulcerogenic activity. Periodontal disease is a complex condition as a result of interaction between microorganisms and host inflammatory mediators. Hence, the extract of is tested for its antibacterial and anti-inflammatory properties against periodontal disease.
The aim of this study is to evaluate the antibacterial property of leaves and seeds against periodontal pathogens, namely , , , and and anti-inflammatory property against matrix metalloproteinase-2 (MMP-2) and MMP-9.
In this study, aqueous extract of is tested for its antibacterial property against the stock cultures of specified periodontal pathogens using the tube dilution method and anti-inflammatory property against MMP-2 and MMP-9 using zymogen gel electrography.
Minimum concentration at which the sensitivity of . , . , . , and . for the extract observed was 50 μl/ml, 0.8 μl/ml, 0.4 μl/ml and 12.5 μl/ml, respectively, concentrations below these showed no effect on the microorganisms. Zymogen electrographic test for anti-inflammatory activity showed percentage inhibition of 30% and 40% against MMP-2 and MMP-9, respectively.
is effective against the periodontal pathogens and inflammatory mediators which are responsible for periodontal disease.
通常被称为（福斯克）是一种多年生草本植物，属于科。从植物提取物中发现了一系列生物活性，包括伤口愈合活性、抗炎、镇痛、抗氧化、弱抗菌、免疫调节和抗溃疡活性。牙周病是微生物与宿主炎症介质相互作用的复杂结果。因此，对的提取物进行了针对牙周病的抗菌和抗炎特性测试。
本研究的目的是评估的叶子和种子对牙周病原体，即、、、的抗菌特性以及对基质金属蛋白酶-2（MMP-2）和MMP-9的抗炎特性。
在本研究中，使用试管稀释法测试的水提取物对特定牙周病原体的储备培养物的抗菌特性，并使用酶原凝胶电泳法测试其对MMP-2和MMP-9的抗炎特性。
观察到提取物对、、、的敏感性的最低浓度分别为50微升/毫升、0.8微升/毫升、0.4微升/毫升和12.5微升/毫升，低于这些浓度对微生物没有影响。抗炎活性的酶原电泳测试显示对MMP-2和MMP-9的抑制率分别为30%和40%。
对导致牙周病的牙周病原体和炎症介质有效。
