Antibacterial and anti-inflammatory properties of Forssk. leaves and seeds against periodontal pathogens: An study.

BACKGROUND

commonly called as ( Forssk.) is a perennial herb that belongs to the family . A range of biological activities has been found from plant extracts, including wound healing activity, anti-inflammatory, analgesic, antioxidant, weak antibiotic, immunomodulating and anti-ulcerogenic activity. Periodontal disease is a complex condition as a result of interaction between microorganisms and host inflammatory mediators. Hence, the extract of is tested for its antibacterial and anti-inflammatory properties against periodontal disease.

AIM

The aim of this study is to evaluate the antibacterial property of leaves and seeds against periodontal pathogens, namely , , , and and anti-inflammatory property against matrix metalloproteinase-2 (MMP-2) and MMP-9.

MATERIALS AND METHODS

In this study, aqueous extract of is tested for its antibacterial property against the stock cultures of specified periodontal pathogens using the tube dilution method and anti-inflammatory property against MMP-2 and MMP-9 using zymogen gel electrography.

RESULTS

Minimum concentration at which the sensitivity of . , . , . , and . for the extract observed was 50 μl/ml, 0.8 μl/ml, 0.4 μl/ml and 12.5 μl/ml, respectively, concentrations below these showed no effect on the microorganisms. Zymogen electrographic test for anti-inflammatory activity showed percentage inhibition of 30% and 40% against MMP-2 and MMP-9, respectively.

CONCLUSION

is effective against the periodontal pathogens and inflammatory mediators which are responsible for periodontal disease.