Recio M C, Giner R M, Máñez S, Ríos J L
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Spain.
Planta Med. 1994 Jun;60(3):232-4. doi: 10.1055/s-2006-959465.
Twelve iridoid glycosides have been evaluated for their anti-inflammatory activity on two models: the carrageenan-induced mouse paw edema and the TPA-induced mouse ear edema. Loganic acid was the most active (44.4% edema inhibition) on the former test, whereas the catalpol derivative mixture isolated from Scrophularia, aucubin, verbenalin, and loganin, showed the highest activity (from 72.0 to 80.0% edema inhibition) on the latter. The results allowed us to establish the relationship between the structure and anti-inflammatory activity on the basis of the different patterns of substitution, particularly hydroxylation, unsaturation, and acylation.
已在两种模型上评估了12种环烯醚萜苷的抗炎活性：角叉菜胶诱导的小鼠足爪水肿模型和佛波酯诱导的小鼠耳水肿模型。在前者的试验中，马钱子酸活性最高（水肿抑制率为44.4%），而从玄参中分离得到的梓醇衍生物混合物、桃叶珊瑚苷、马鞭草苷和马钱子苷，在后者的试验中显示出最高活性（水肿抑制率为72.0%至80.0%）。基于不同的取代模式，特别是羟基化、不饱和化和酰化，这些结果使我们能够建立结构与抗炎活性之间的关系。
