Fedeli Ugo, Avossa Francesco, Ferroni Eliana, De Paoli Angela, Donato Francesco, Corti Maria Chiara
Epidemiological Department, Azienda Zero, Passaggio Gaudenzio 1, 35131 Padova, Veneto Region, Italy.
Unit of Hygiene, Epidemiology, and Public Health, University of Brescia, v.le Europa, 11, 25121 Brescia, Italy.
Heliyon. 2019 Jul 18;5(7):e02114. doi: 10.1016/j.heliyon.2019.e02114. eCollection 2019 Jul.
Sparse population-based data are available on the prevalence and etiology of chronic liver disease (CLD) in Italy. The study aims to assess the role of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in CLD according to age, gender and ethnicity.
Clinically diagnosed CLD in the general population aged 20-59 years in the Veneto Region (North-Eastern Italy) were identified through the Adjusted Clinical Groups System, by record linkage of the archive of subjects enrolled in the Regional Health System with Hospital Discharge Records, Emergency Room visits, Chronic disease registry for copayment exemptions, and the Home care database. Age-standardized prevalence rates (PR) were computed in Italians and immigrants, based on country of citizenship.
Overall 22,934 subjects affected by CLD in 2016 were retrieved, 21% related to HBV and 43% to HCV infection. The prevalence of HCV-related CLD was higher in males, peaking at 50-54 years (males = 11/1000; females = 4/1000). The PR of HBV-related CLD was almost negligible in the Italian population (1/1000), and higher among immigrants, especially from East Asia (males = 17/1000; females = 11/1000) and Sub-Saharan Africa (males = 13/1000; females = 10/1000).
Specific population sub-groups identified by age, gender, and ethnicity, were demonstrated to be at increased risk, and these trends are in line with global epidemiological patterns of viral hepatitis.
关于意大利慢性肝病（CLD）的患病率和病因，基于人群的稀疏数据可用。本研究旨在根据年龄、性别和种族评估乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染在CLD中的作用。
通过调整后的临床分组系统，将参与地区卫生系统的受试者档案与医院出院记录、急诊室就诊记录、慢性病共付豁免登记册和家庭护理数据库进行记录链接，以识别威尼托地区（意大利东北部）20 - 59岁普通人群中临床诊断的CLD。根据公民国籍，计算意大利人和移民的年龄标准化患病率（PR）。
2016年共检索到22,934例受CLD影响的受试者，其中21%与HBV感染有关，43%与HCV感染有关。HCV相关CLD的患病率在男性中较高，在50 - 54岁达到峰值（男性 = 11/1000；女性 = 4/1000）。HBV相关CLD的PR在意大利人群中几乎可以忽略不计（1/1000），而在移民中较高，尤其是来自东亚（男性 = 17/1000；女性 = 11/1000）和撒哈拉以南非洲（男性 = 13/1000；女性 = 10/1000）的移民。
按年龄、性别和种族确定的特定人群亚组被证明风险增加，这些趋势与病毒性肝炎的全球流行病学模式一致。
