Hyland Michael E, Bacon Alison M, Lanario Joseph W, Davies Anthony F
School of Psychology, University of Plymouth, Plymouth, PL4 8AA, UK.
Peninsula Medical School, University of Plymouth, Plymouth, PL4 8AA, UK.
Chronic Dis Transl Med. 2019 Jun 24;5(2):129-138. doi: 10.1016/j.cdtm.2019.05.003. eCollection 2019 Jun.
To describe the extent to which irritable bowel syndrome (IBS), fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS) exhibit symptom overlap, and to validate a patient-derived, generic symptom questionnaire.
A patient-derived 61-item symptom-frequency questionnaire was completed by participants recruited through IBS, FMS and CFS self-help websites. Principal axis factor analysis with oblimin rotation was performed separately for those reporting an IBS, FMS or CFS diagnosis.
Questionnaires were completed by 1751 participants of whom 851 reported more than one of the three diagnoses. Stomach pain on at least a weekly basis was reported by 79% of IBS, 52% of FMS, and 43% of CFS single diagnosis participants. Pain increasing the day after activity was reported by 32% of IBS, 94% of FMS, and 85% of CFS single diagnosis participants. Waking still tired at least once weekly was reported by 75% of IBS, 97% of FMS, and 95% of CFS single diagnosis participants. Exploratory factor analysis produced consistent results across all three diagnostic groups, the 61 items loading on 12 correlated factors with a single higher order factor on which all items loaded. Frequency analysis led to the rejection of one item (cold sores on or near lips), and freeform reporting by participants of additional symptoms identified an additional five, namely, restless legs, hair loss/brittle hair/thinning, dizziness/balance problems, blurred vision and urination problems.
IBS, FMS and CFS are polysymptomatic spectrum disorders with a wide range of overlapping symptoms, many of which are unrelated to diagnostic criteria. Frequency analysis and factor analysis confirm the validity of using the same questionnaire across different diagnostic categories. The 65-item general symptom questionnaire (GSQ-65) is a valid generic symptom scale suitable for assessing the many different symptoms of people with IBS, FMS and CFS.
描述肠易激综合征（IBS）、纤维肌痛综合征（FMS）和慢性疲劳综合征（CFS）症状重叠的程度，并验证一份源自患者的通用症状问卷。
通过IBS、FMS和CFS自助网站招募参与者，让他们完成一份源自患者的包含61个项目的症状频率问卷。对报告患有IBS、FMS或CFS诊断的参与者分别进行主成分因子分析并采用斜交旋转。
1751名参与者完成了问卷，其中851人报告患有三种诊断中的不止一种。在仅诊断为IBS的参与者中，79%报告至少每周有一次胃痛；仅诊断为FMS的参与者中，52%报告有此症状；仅诊断为CFS的参与者中，43%报告有此症状。在仅诊断为IBS的参与者中，32%报告活动后次日疼痛加剧；仅诊断为FMS的参与者中，94%报告有此症状；仅诊断为CFS的参与者中，85%报告有此症状。在仅诊断为IBS的参与者中，75%报告至少每周有一次醒来仍感到疲倦；仅诊断为FMS的参与者中，97%报告有此症状；仅诊断为CFS的参与者中，95%报告有此症状。探索性因子分析在所有三个诊断组中产生了一致的结果，61个项目加载在12个相关因子上，所有项目都加载在一个单一的高阶因子上。频率分析导致剔除了一个项目（嘴唇上或附近的唇疱疹），参与者对其他症状的自由报告又识别出另外五个症状，即不安腿、脱发/头发脆弱/变细、头晕/平衡问题、视力模糊和排尿问题。
IBS、FMS和CFS是多症状谱疾病，有广泛的重叠症状，其中许多与诊断标准无关。频率分析和因子分析证实了在不同诊断类别中使用相同问卷的有效性。这份包含65个项目的通用症状问卷（GSQ - 65）是一个有效的通用症状量表，适用于评估患有IBS、FMS和CFS的人群的多种不同症状。
