Tarar Zahid Ijaz, Farooq Umer, Nawaz Ahmad, Gandhi Mustafa, Ghouri Yezaz A, Bhatt Asmeen, Cash Brooks D
Division of Gastroenterology and Hepatology, University of Missouri School of Medicine, Columbia, MO 65212, USA.
Division of Gastroenterology and Hepatology, Saint Louis University, St. Louis, MO 63103, USA.
Biomedicines. 2023 Sep 22;11(10):2594. doi: 10.3390/biomedicines11102594.
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with other somatic disorders. We studied the prevalence and predictors of fibromyalgia and chronic fatigue syndrome (CFS) in IBS patients. We used the National Inpatient Sample and included hospitalization of individuals with IBS, using ICD-10 codes, from 2016-2019. The prevalence and predictors of fibromyalgia and CFS in IBS patients were studied. Univariate and multivariate patient- and hospital-level regression models were used to calculate the adjusted odds of fibromyalgia and CFS in the IBS patient population. Of 1,256,325 patients with an ICD-10 code of IBS included in the study, 10.73% (134,890) also had ICD-10 codes for fibromyalgia and 0.42% (5220) for CFS. The prevalence of fibromyalgia and CFS was significantly higher in IBS patients (adjusted odds ratio (AOR) 5.33, 95% confidence interval (CI) 5.24-5.41, < 0.001, and AOR 5.40, 95% CI 5.04-5.78, < 0.001, respectively) compared to the general adult population without IBS. IBS-diarrhea, IBS-constipation, and IBS-mixed types were independently associated with increased odds of fibromyalgia and CFS. Increasing age (AOR 1.02, 95% CI 1.01-1.04, 0.003; AOR 1.02, 95% CI 1.01-1.03, 0.001), female gender (AOR 11.2, 95% CI 11.1-11.4, < 0.001; AOR 1.86, 95% CI 1.78-1.93, < 0.001) and white race (AOR 2.04, 95% CI 1.95-2.12, < 0.001; AOR 1.69, 95% CI 1.34-2.13, < 0.001) were independent predictors of increased odds of fibromyalgia and CFS, respectively. It appears that IBS is associated with an increased prevalence of somatic disorders such as fibromyalgia and CFS.
肠易激综合征（IBS）是一种与其他躯体疾病相关的功能性胃肠疾病。我们研究了IBS患者中纤维肌痛和慢性疲劳综合征（CFS）的患病率及预测因素。我们使用了国家住院患者样本，纳入了2016年至2019年使用ICD - 10编码诊断为IBS的患者的住院病例。对IBS患者中纤维肌痛和CFS的患病率及预测因素进行了研究。使用单变量和多变量患者及医院层面的回归模型来计算IBS患者群体中纤维肌痛和CFS的调整后比值比。在纳入研究的1,256,325例ICD - 10编码为IBS的患者中，10.73%（134,890例）同时有纤维肌痛的ICD - 10编码，0.42%（5220例）有CFS的ICD - 10编码。与无IBS的普通成年人群相比，IBS患者中纤维肌痛和CFS的患病率显著更高（调整后比值比（AOR）分别为5.33，95%置信区间（CI）为5.24 - 5.41，P < 0.001；以及AOR为5.40，95% CI为5.04 - 5.78，P < 0.001）。IBS腹泻型、IBS便秘型和IBS混合型与纤维肌痛和CFS的患病几率增加独立相关。年龄增长（AOR为1.02，95% CI为1.01 - 1.04，P = 0.003；AOR为1.02，95% CI为1.01 - 1.03，P = 0.001）、女性（AOR为11.2，95% CI为11.1 - 11.4，P < 0.001；AOR为1.86，95% CI为1.78 - 1.93，P < 0.001）和白人种族（AOR为2.04，95% CI为1.95 - 2.12，P < 0.001；AOR为1.69，95% CI为1.34 - 2.13，P < 0.001）分别是纤维肌痛和CFS患病几率增加的独立预测因素。看来IBS与纤维肌痛和CFS等躯体疾病的患病率增加有关。
