一种用于单活细胞中端粒酶活性的双模式成像和检测的跷跷板比率探针。
A seesaw ratiometric probe for dual-spectrum imaging and detection of telomerase activity in single living cells.
机构信息
Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
出版信息
Chem Commun (Camb). 2019 Aug 15;55(67):9967-9970. doi: 10.1039/c9cc03870a.
Herein, a seesaw ratiometric (SR) probe is designed which integrates fluorescence and surface enhanced Raman scattering (SERS) technology. Fluorescence imaging enables tracking of the spatiotemporal dynamic behaviour of telomerase. Meanwhile, SERS reverse ratiometric measurement can enable sensitive detection of telomerase activity in single living cells.
在此，设计了一种跷跷板比率（SR）探针，它集成了荧光和表面增强拉曼散射（SERS）技术。荧光成像是跟踪端粒酶时空动态行为的有力工具。同时，SERS 反向比率测量可以实现对单个活细胞中端粒酶活性的灵敏检测。
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