Inzhevatkin E V, Savchenko A A
International Scientific Center for Organism Extreme Conditions Research, Federal Research Center "Krasnoyarsk Science Center," Siberian Branch, Russian Academy of Sciences, 630036, Krasnoyarsk, Russia.
Institute of Medical Problems of the North, Federal Research Center "Krasnoyarsk Science Center," Siberian Branch, Russian Academy of Sciences, 630036, Krasnoyarsk, Russia.
Dokl Biochem Biophys. 2019 May;486(1):234-237. doi: 10.1134/S1607672919030177. Epub 2019 Jul 31.
In this work, we investigated the NAD(P)-dependent dehydrogenase activity in different fields of the solid form of Ehrlich carcinoma. It was shown that there is a metabolic distinction between different fields of the solid tumor. In this way, there is a significant difference between the ascites and solid type of Ehrlich carcinoma. In the central area of the tested sample of tumor tissue, there is a high intensity of energetic metabolism and biosynthetic processes as opposed to the peripheral areas. Previously, we proposed the concept of nonspecific metabolic reaction of the cell in organism upon the influence of negative factors. In accordance with this concept, our results indicate the development of adaptation in the tumor cells in the central area of the tested sample.
在这项工作中，我们研究了艾氏腹水癌实体瘤不同区域的NAD(P)依赖性脱氢酶活性。结果表明，实体瘤的不同区域存在代谢差异。因此，艾氏腹水癌的腹水型和实体型之间存在显著差异。在肿瘤组织测试样本的中心区域，与周边区域相比，存在高强度的能量代谢和生物合成过程。此前，我们提出了机体中细胞在负面因素影响下的非特异性代谢反应概念。根据这一概念，我们的结果表明测试样本中心区域的肿瘤细胞发生了适应性变化。
