Inzhevatkin E V, Savchenko A A
Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS, Akademgorodok 50, Krasnoyarsk, 660036, Russia.
Research Institute for Medical Problems in the North Division of Federal Research Center "Krasnoyarsk Scientific Center of the Siberian Branch of the RAS", ul. Partizana Zheleznyaka 3 G, Krasnoyarsk, 660022, Russia.
Dokl Biochem Biophys. 2017 Jul;475(1):277-279. doi: 10.1134/S1607672917040081. Epub 2017 Sep 2.
In this work, we investigated the activity of the key NAD(P)-dependent dehydrogenases associated with macrophage tumors in mice with Ehrlich ascites carcinoma. It was shown that cancer grow is associated with the development of conditions in macrophages leading to a decrease in the substrate flow intensity in the tricarboxylic acid cycle, deceleration of oxidative deamination of L-glutamate, NADP regeneration, and a decrease in the antioxidant defense efficiency. There results are consistent with our recent concept on the nonspecific metabolic reaction of cells to extreme exposures.
在这项工作中，我们研究了艾氏腹水癌小鼠巨噬细胞肿瘤相关的关键NAD(P)依赖性脱氢酶的活性。结果表明，癌症生长与巨噬细胞中条件的发展相关，这导致三羧酸循环中底物流动强度降低、L-谷氨酸氧化脱氨基减速、NADP再生以及抗氧化防御效率降低。这些结果与我们最近关于细胞对极端暴露的非特异性代谢反应的概念一致。
