The metabolic changes in tumor-associated macrophages during cancer grow in mice with Ehrlich ascites carcinoma.
作者信息
Inzhevatkin E V, Savchenko A A
机构信息
Federal Research Center Krasnoyarsk Scientific Center of the Siberian Branch of the RAS, Akademgorodok 50, Krasnoyarsk, 660036, Russia.
Research Institute for Medical Problems in the North Division of Federal Research Center "Krasnoyarsk Scientific Center of the Siberian Branch of the RAS", ul. Partizana Zheleznyaka 3 G, Krasnoyarsk, 660022, Russia.
出版信息
Dokl Biochem Biophys. 2017 Jul;475(1):277-279. doi: 10.1134/S1607672917040081. Epub 2017 Sep 2.
In this work, we investigated the activity of the key NAD(P)-dependent dehydrogenases associated with macrophage tumors in mice with Ehrlich ascites carcinoma. It was shown that cancer grow is associated with the development of conditions in macrophages leading to a decrease in the substrate flow intensity in the tricarboxylic acid cycle, deceleration of oxidative deamination of L-glutamate, NADP regeneration, and a decrease in the antioxidant defense efficiency. There results are consistent with our recent concept on the nonspecific metabolic reaction of cells to extreme exposures.
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