SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ronda de Toledo 12, 13071, Ciudad Real, Spain.
Sabiotec, S.A. Ed. Polivalente UCLM, Camino de Moledores, 13005, Ciudad Real, Spain.
Exp Appl Acarol. 2019 Aug;78(4):555-564. doi: 10.1007/s10493-019-00408-x. Epub 2019 Jul 31.
Blood-feeding ectoparasites constitute a growing burden for human and animal health, and animal production worldwide. In particular, mites (Acari: Gamasida) of the genera Dermanyssus (Dermanyssidae) and Ornithonyssus (Macronyssidae) infest birds and cause gamasoidosis in humans. The tropical fowl mite, Ornithonyssus bursa, is commonly found in tropical and subtropical countries but rarely reported in Europe. In this research we characterized the first two cases in Spain of clinical gamasoidosis diagnosed in patients infested with O. bursa, and investigated the IgE, IgM and IgG antibody response to mite proteins and the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) involved in the tick-bite associated alpha-Gal syndrome (AGS). The results suggested that O. bursa is establishing across Mediterranean countries, and may increase the risk for gamasoidosis. The immune antibody response to mite proteins was higher for IgM and similar for IgE and IgG antibodies between patients and non-allergic control individuals exposed to mite or tick bites. The anti-α-Gal antibody levels were similar between patients and controls, a result supported by the absence of this carbohydrate in mites. These results suggested that mite bites do not correlate with antibody response to acarine proteins or α-Gal, and are not associated with the AGS.
吸血外寄生虫对全球人类和动物健康以及动物生产构成了日益严重的负担。特别是螨类（节肢动物门：革螨目）属的德氏血螨（血螨科）和禽刺螨（禽刺螨科）寄生鸟类，并导致人类的革螨病。热带鸡螨，禽刺螨，常见于热带和亚热带国家，但在欧洲很少报道。在这项研究中，我们对西班牙首例由 O. bursa 寄生引起的临床革螨病患者进行了描述，并调查了针对螨蛋白和参与与蜱叮咬相关的α-半乳糖综合征（AGS）的碳水化合物 Galα1-3Galβ1-(3)4GlcNAc-R（α-Gal）的 IgE、IgM 和 IgG 抗体反应。结果表明，O. bursa 正在跨越地中海国家建立，并可能增加革螨病的风险。与暴露于螨或蜱叮咬的非过敏对照个体相比，患者的 IgM 对螨蛋白的免疫抗体反应更高，而 IgE 和 IgG 抗体相似。患者和对照组之间的抗-α-Gal 抗体水平相似，这一结果得到了螨类中不存在这种碳水化合物的支持。这些结果表明，螨类叮咬与针对革螨蛋白或α-Gal 的抗体反应无关，也与 AGS 无关。
