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用重组阿基林免疫的母鸡中家禽红螨产卵量的减少

Reduction in Oviposition of Poultry Red Mite () in Hens Vaccinated with Recombinant Akirin.

作者信息

Lima-Barbero Jose Francisco, Contreras Marinela, Bartley Kathryn, Price Daniel R G, Nunn Francesca, Sanchez-Sanchez Marta, Prado Eduardo, Höfle Ursula, Villar Margarita, Nisbet Alasdair J, de la Fuente José

机构信息

SaBio, Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo 12, 13071 Ciudad Real, Spain.

Sabiotec, Ed. Polivalente UCLM, Camino de Moledores s/n, 13005 Ciudad Real, Spain.

出版信息

Vaccines (Basel). 2019 Sep 19;7(3):121. doi: 10.3390/vaccines7030121.

DOI:10.3390/vaccines7030121
PMID:31546944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6789658/
Abstract

The poultry red mite (PRM), , is a hematophagous ectoparasite of birds with worldwide distribution that causes economic losses in the egg-production sector of the poultry industry. Traditional control methods, mainly based on acaricides, have been only partially successful, and new vaccine-based interventions are required for the control of PRM. Vaccination with insect Akirin (AKR) and its homolog in ticks, Subolesin (SUB), have shown protective efficacy for the control of ectoparasite infestations and pathogen infection/transmission. The aim of this study was the identification of the akr gene from (), the production of the recombinant Deg-AKR protein, and evaluation of its efficacy as a vaccine candidate for the control of PRM. The anti-Deg-AKR serum IgY antibodies in hen sera and egg yolk were higher in vaccinated than control animals throughout the experiment. The results demonstrated the efficacy of the vaccination with Deg-AKR for the control of PRM by reducing mite oviposition by 42% following feeding on vaccinated hens. A negative correlation between the levels of serum anti-Deg-AKR IgY and mite oviposition was obtained. These results support Deg-AKR as a candidate protective antigen for the control of PRM population growth.

摘要

禽红螨（PRM）是一种寄生于鸟类的吸血外寄生虫，分布于世界各地，给家禽业的蛋生产部门造成经济损失。传统的控制方法主要基于杀螨剂，但仅取得了部分成功，因此需要新的基于疫苗的干预措施来控制禽红螨。用昆虫Akirin（AKR）及其蜱类同源物Subolesin（SUB）进行疫苗接种，已显示出对控制外寄生虫感染和病原体感染/传播的保护效果。本研究的目的是从（）中鉴定akr基因，生产重组Deg-AKR蛋白，并评估其作为控制禽红螨疫苗候选物的功效。在整个实验过程中，接种疫苗的母鸡血清和蛋黄中的抗Deg-AKR血清IgY抗体高于对照动物。结果表明，用Deg-AKR疫苗接种可有效控制禽红螨，接种疫苗的母鸡被采食后，螨的产卵量减少了42%。血清抗Deg-AKR IgY水平与螨产卵量之间呈负相关。这些结果支持Deg-AKR作为控制禽红螨种群增长的候选保护性抗原。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/65e96698d38d/vaccines-07-00121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/afd225ba1811/vaccines-07-00121-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/f57edb5c86d0/vaccines-07-00121-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/3627c475b0c9/vaccines-07-00121-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/65e96698d38d/vaccines-07-00121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/afd225ba1811/vaccines-07-00121-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/f57edb5c86d0/vaccines-07-00121-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/3627c475b0c9/vaccines-07-00121-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0882/6789658/65e96698d38d/vaccines-07-00121-g004.jpg

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