精神病患者中促甲状腺激素对促甲状腺激素释放激素的反应及氟哌啶醇反应潜伏期

TSH response to TRH and haloperidol response latency in psychoses.

作者信息

Beasley C M, Magnusson M, Garver D L

机构信息

University of Cincinnati, College of Medicine, Department of Psychiatry, OH 45262.

出版信息

Biol Psychiatry. 1988 Aug;24(4):423-31. doi: 10.1016/0006-3223(88)90179-5.

DOI:10.1016/0006-3223(88)90179-5

PMID:3136807

Abstract

Thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) was measured in 19 acutely psychotic (DSM-III schizophrenia, 7; schizophreniform, 2; schizoaffective, 3; affective, mood-incongruent psychosis, 5; manic, mood-congruent psychosis, 2) drug-free patients prior to systematic trials of lithium and/or haloperidol. TSH response was not associated with sex, age, baseline T4, or baseline TSH. A reduced TSH response was associated with affective diagnosis and was a significant predictor of a positive, rapid response to neuroleptic treatment.

摘要

在对19名急性精神病性（DSM-III精神分裂症7例；分裂样精神病2例；分裂情感性精神病3例；情感性、心境不协调性精神病5例；躁狂症、心境协调性精神病2例）未用药患者进行锂盐和/或氟哌啶醇系统试验之前，测量了促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应。TSH反应与性别、年龄、基线T4或基线TSH无关。TSH反应降低与情感性诊断相关，并且是对抗精神病药物治疗呈阳性、快速反应的重要预测指标。